Homo sapiens Gene: QARS
Summary
InnateDB Gene IDBG-34287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QARS
Gene Name glutaminyl-tRNA synthetase
Synonyms GLNRS; MSCCA; PRO2195;
Species Homo sapiens
Ensembl Gene ENSG00000172053
Encoded Proteins
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49095932-49105101
Strand Reverse strand
Band p21.31
Transcripts
ENST00000306125 ENSP00000307567
ENST00000453392 ENSP00000396326
ENST00000430182 ENSP00000389823
ENST00000414533 ENSP00000390015
ENST00000452739 ENSP00000392850
ENST00000418549 ENSP00000415247
ENST00000417025 ENSP00000414686
ENST00000482248
ENST00000475599
ENST00000487495
ENST00000497635
ENST00000494984
ENST00000464962
ENST00000459870
ENST00000470113
ENST00000466179
ENST00000482468
ENST00000478561
ENST00000494838
ENST00000470225
ENST00000494767
ENST00000482261
ENST00000470619
ENST00000479495
ENST00000482438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
Experimentally validated
Total 120 [view]
Protein-Protein 120 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004819 glutamine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0010467 gene expression
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
Mitochondrial tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
Glutamate Glutamine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.630416 Hs.79322
RefSeq NM_001272073 NM_005051
HUGO
OMIM
CCDS CCDS2788 CCDS63633
HPRD 07223
IMGT
EMBL
GenPept
RNA Seq Atlas