Homo sapiens Gene: PSMC2
Summary
InnateDB Gene IDBG-34377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMC2
Gene Name proteasome (prosome, macropain) 26S subunit, ATPase, 2
Synonyms MSS1; Nbla10058; S7
Species Homo sapiens
Ensembl Gene ENSG00000161057
Encoded Proteins
proteasome (prosome, macropain) 26S subunit, ATPase, 2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:103344254-103369395
Strand Forward strand
Band q22.1
Transcripts
ENST00000292644 ENSP00000292644
ENST00000457587 ENSP00000401724
ENST00000425206 ENSP00000393027
ENST00000435765 ENSP00000391211
ENST00000460021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 145 [view]
Protein-Protein 144 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0001649 osteoblast differentiation
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006200 ATP catabolic process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0030163 protein catabolic process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Cellular Component
GO:0000502 proteasome complex
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0022624 proteasome accessory complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
TNFalpha pathway
REACTOME
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Stabilization of p53 pathway
p53-Dependent G1 DNA Damage Response pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
p53-Independent DNA Damage Response pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Separation of Sister Chromatids pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the pre-replicative complex pathway
Cyclin E associated events during G1/S transition pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
ER-Phagosome pathway pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Activation of NF-kappaB in B cells pathway
Degradation of beta-catenin by the destruction complex pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Regulation of ornithine decarboxylase (ODC) pathway
Vif-mediated degradation of APOBEC3G pathway
Vpu mediated degradation of CD4 pathway
DNA Replication pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Regulation of mitotic cell cycle pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Metabolism of amino acids and derivatives pathway
Immune System pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
M/G1 Transition pathway
degradation of AXIN pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
G1/S DNA Damage Checkpoints pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Proteasome pathway
INOH
TGF-beta signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437366 Hs.667881 Hs.681836
RefSeq NM_001204453 NM_002803
HUGO
OMIM
CCDS CCDS5731
HPRD 01105
IMGT
EMBL
GenPept
RNA Seq Atlas