Homo sapiens Gene: KRT5
Summary
InnateDB Gene IDBG-34676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT5
Gene Name keratin 5
Synonyms CK5; DDD; DDD1; EBS2; K5; KRT5A;
Species Homo sapiens
Ensembl Gene ENSG00000186081
Encoded Proteins
keratin 5
keratin 5
keratin 5
keratin 5
keratin 5
keratin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52514575-52520687
Strand Reverse strand
Band q13.13
Transcripts
ENST00000252242 ENSP00000252242
ENST00000552952
ENST00000549511
ENST00000548409 ENSP00000448767
ENST00000552629
ENST00000547890
ENST00000551013
ENST00000551188 ENSP00000449783
ENST00000549420 ENSP00000447209
ENST00000551275 ENSP00000448041
ENST00000546577 ENSP00000449651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0008544 epidermis development
GO:0031581 hemidesmosome assembly
GO:0034329 cell junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Cell-Cell communication pathway
Cell junction organization pathway
Type I hemidesmosome assembly pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Glucocorticoid receptor regulatory network
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL F8W0C6
UniProt Splice Variant
Entrez Gene 3852
UniGene Hs.433845
RefSeq NM_000424
HUGO HGNC:6442
OMIM 148040
CCDS CCDS8830
HPRD 01010
IMGT
EMBL AC055736
GenPept
RNA Seq Atlas 3852