Homo sapiens Gene: RHOA
Summary
InnateDB Gene IDBG-34732.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOA
Gene Name ras homolog family member A
Synonyms ARH12; ARHA; RHO12; RHOH12;
Species Homo sapiens
Ensembl Gene ENSG00000067560
Encoded Proteins
ras homolog gene family, member A
ras homolog gene family, member A
ras homolog gene family, member A
ras homolog gene family, member A
ras homolog gene family, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49359145-49412998
Strand Reverse strand
Band p21.31
Transcripts
ENST00000265538
ENST00000418115 ENSP00000400175
ENST00000454011 ENSP00000394483
ENST00000422781 ENSP00000413587
ENST00000445425 ENSP00000408402
ENST00000431929 ENSP00000400747
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 171 [view]
Protein-Protein 169 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017022 myosin binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016032 viral process
GO:0021762 substantia nigra development
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030334 regulation of cell migration
GO:0032467 positive regulation of cytokinesis
GO:0033688 regulation of osteoblast proliferation
GO:0036089 cleavage furrow formation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297 apical junction assembly
GO:0043931 ossification involved in bone maturation
GO:0045666 positive regulation of neuron differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051496 positive regulation of stress fiber assembly
GO:0061383 trabecula morphogenesis
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0043296 apical junction complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
TGF_beta_Receptor pathway
Wnt pathway
TSH pathway
REACTOME
PCP/CE pathway pathway
Sema4D in semaphorin signaling pathway
G alpha (12/13) signalling events pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Developmental Biology pathway
Signalling by NGF pathway
PI3K/AKT activation pathway
p75NTR regulates axonogenesis pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
beta-catenin independent WNT signaling pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
Signaling by Rho GTPases pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Axon guidance pathway
Axonal growth stimulation pathway
p75 NTR receptor-mediated signalling pathway
Axonal growth inhibition (RHOA activation) pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
GPCR downstream signaling pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
EPHA-mediated growth cone collapse pathway
GPVI-mediated activation cascade pathway
Rho GTPase cycle pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
TGFBR1 KD Mutants in Cancer pathway
EPH-Ephrin signaling pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
G beta:gamma signalling through PI3Kgamma pathway
Sema4D induced cell migration and growth-cone collapse pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Disease pathway
Hemostasis pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
T cell receptor signaling pathway pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pancreatic secretion pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Ucalpain and friends in cell spread [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Integrin signaling pathway [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Ras signaling pathway [Biocarta view]
Rho-selective guanine exchange factor akap13 mediates stress fiber formation [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
D4gdi signaling pathway [Biocarta view]
Protein kinase a at the centrosome [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
EPHA forward signaling
Thromboxane A2 receptor signaling
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events
S1P1 pathway
LPA receptor mediated events
IL2-mediated signaling events
Netrin-mediated signaling events
Integrins in angiogenesis
S1P2 pathway
Signaling events mediated by PTP1B
PAR1-mediated thrombin signaling events
Signaling events mediated by focal adhesion kinase
Regulation of RhoA activity
p75(NTR)-mediated signaling
Signaling events mediated by PRL
S1P5 pathway
S1P3 pathway
S1P4 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Plasma membrane estrogen receptor signaling
PAR4-mediated thrombin signaling events
Signaling events regulated by Ret tyrosine kinase
SHP2 signaling
Arf6 downstream pathway
RhoA signaling pathway
Noncanonical Wnt signaling pathway
EPHA2 forward signaling
Aurora B signaling
a4b7 Integrin signaling
Stabilization and expansion of the E-cadherin adherens junction
Lissencephaly gene (LIS1) in neuronal migration and development
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
amb2 Integrin signaling
Endogenous TLR signaling
N-cadherin signaling events
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.247077
RefSeq NM_001664
HUGO
OMIM
CCDS CCDS2795
HPRD 01323
IMGT
EMBL
GenPept
RNA Seq Atlas