Version 5.4
Homo sapiens Gene: MFAP4
Summary
InnateDB Gene IDBG-34759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFAP4
Gene Name microfibrillar-associated protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166482
Encoded Proteins
IDBP-34761
microfibrillar-associated protein 4
IDBP-239238
microfibrillar-associated protein 4
IDBP-764132
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:19383442-19387240
Strand Reverse strand
Band p11.2
Transcripts
ENST00000299610 ENSP00000299610
ENST00000395592 ENSP00000378957
ENST00000497081 ENSP00000468578
ENST00000574313
ENST00000571210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0009650 UV protection
GO:0010712 regulation of collagen metabolic process
GO:0030198 extracellular matrix organization
GO:0043206 extracellular fibril organization
GO:0048251 elastic fiber assembly
GO:0071493 cellular response to UV-B
Cellular Component
GO:0001527 microfibril
GO:0005576 extracellular region
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
GO:0071953 elastic fiber
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042436
View Gene Order
ENSBTAG00000006187
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0A024QZ34
UniProt Splice Variant
Entrez Gene 4239
UniGene Hs.296049 Hs.706535
RefSeq NM_001198695 NM_002404
HUGO HGNC:7035
OMIM 600596
CCDS CCDS56023 CCDS11208
HPRD 02789
IMGT
EMBL CH471212
GenPept EAW50890
RNA Seq Atlas 4239

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca