InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TSG101

Summary

InnateDB Gene

IDBG-35022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSG101

Gene Name

tumor susceptibility gene 101

Synonyms

TSG10; VPS23

Species

Homo sapiens

Ensembl Gene

ENSG00000074319

Encoded Proteins

IDBP-35024

tumor susceptibility gene 101

IDBP-594023

tumor susceptibility gene 101

IDBP-718908

IDBP-719145

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:18468336-18527232

Strand

Reverse strand

Band

p15.1

Transcripts

ENST00000251968	ENSP00000251968
ENST00000438874
ENST00000536719	ENSP00000438471
ENST00000540555
ENST00000545247
ENST00000543054
ENST00000543087
ENST00000544804
ENST00000542488
ENST00000535077
ENST00000584526	ENSP00000463213
ENST00000580814	ENSP00000464386

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	146 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0043130	ubiquitin binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006464	cellular protein modification process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046755	non-lytic virus budding
GO:0051301	cell division
GO:0061024	membrane organization
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000813	ESCRT I complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome