Homo sapiens Gene: TSG101
Summary
InnateDB Gene IDBG-35022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSG101
Gene Name tumor susceptibility gene 101
Synonyms TSG10; VPS23;
Species Homo sapiens
Ensembl Gene ENSG00000074319
Encoded Proteins
tumor susceptibility gene 101
tumor susceptibility gene 101
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:18468336-18527232
Strand Reverse strand
Band p15.1
Transcripts
ENST00000251968 ENSP00000251968
ENST00000438874
ENST00000536719 ENSP00000438471
ENST00000540555
ENST00000545247
ENST00000543054
ENST00000543087
ENST00000544804
ENST00000542488
ENST00000535077
ENST00000584526 ENSP00000463213
ENST00000580814 ENSP00000464386
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 149 [view]
Protein-Protein 146 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006464 cellular protein modification process
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0019082 viral protein processing
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046755 non-lytic virus budding
GO:0051301 cell division
GO:0061024 membrane organization
GO:0075733 intracellular transport of virus
Cellular Component
GO:0000813 ESCRT I complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Late Phase of HIV Life Cycle pathway
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Assembly Of The HIV Virion pathway
Budding and maturation of HIV virion pathway
Membrane binding and targetting of GAG proteins pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Internalization of ErbB1
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006292 XM_005253107
HUGO
OMIM
CCDS CCDS7842
HPRD 03229
IMGT
EMBL
GenPept
RNA Seq Atlas