Version 5.4
Homo sapiens Gene: MTSS1
Summary
InnateDB Gene IDBG-35101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTSS1
Gene Name metastasis suppressor 1
Synonyms MIM; MIMA; MIMB
Species Homo sapiens
Ensembl Gene ENSG00000170873
Encoded Proteins
IDBP-35103
metastasis suppressor 1
IDBP-35105
metastasis suppressor 1
IDBP-376144
metastasis suppressor 1
IDBP-479448
metastasis suppressor 1
IDBP-481212
metastasis suppressor 1
IDBP-476459
metastasis suppressor 1
IDBP-479583
metastasis suppressor 1
IDBP-473911
metastasis suppressor 1
IDBP-476102
metastasis suppressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:124550790-124728429
Strand Reverse strand
Band q24.13
Transcripts
ENST00000325064 ENSP00000322804
ENST00000378017 ENSP00000367256
ENST00000431961 ENSP00000393606
ENST00000518547 ENSP00000429064
ENST00000520771
ENST00000519168 ENSP00000428685
ENST00000523587
ENST00000524090 ENSP00000428319
ENST00000523179 ENSP00000428348
ENST00000520094
ENST00000522722
ENST00000522118 ENSP00000428145
ENST00000519226
ENST00000522162 ENSP00000429752
ENST00000519671
ENST00000524243
ENST00000472084
ENST00000529463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0017124 SH3 domain binding
GO:0042802 identical protein binding
GO:0051015 actin filament binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006928 cellular component movement
GO:0007009 plasma membrane organization
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010960 magnesium ion homeostasis
GO:0030035 microspike assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030282 bone mineralization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0034334 adherens junction maintenance
GO:0046847 filopodium assembly
GO:0050680 negative regulation of epithelial cell proliferation
GO:0061333 renal tubule morphogenesis
GO:0071498 cellular response to fluid shear stress
GO:0072001 renal system development
GO:0072102 glomerulus morphogenesis
GO:0072160 nephron tubule epithelial cell differentiation
GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005912 adherens junction
GO:0015629 actin cytoskeleton
GO:0030139 endocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022353
View Gene Order
ENSBTAG00000020407
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9788
UniGene Hs.336994 Hs.595842 Hs.670646
RefSeq NM_001282971 NM_001282974 NM_014751 XM_006716704
HUGO HGNC:20443
OMIM 608486
CCDS CCDS6353 CCDS64968 CCDS64969
HPRD 12243
IMGT
EMBL
GenPept
RNA Seq Atlas 9788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca