InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DCC

Summary

InnateDB Gene

IDBG-3511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCC

Gene Name

deleted in colorectal carcinoma

Synonyms

CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1

Species

Homo sapiens

Ensembl Gene

ENSG00000187323

Encoded Proteins

IDBP-3513

deleted in colorectal carcinoma

IDBP-369962

deleted in colorectal carcinoma

IDBP-369978

deleted in colorectal carcinoma

IDBP-727921

IDBP-725770

IDBP-727891

IDBP-725540

IDBP-725562

IDBP-727607

IDBP-727459

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:52340172-53535903

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000304775	ENSP00000304146
ENST00000442544	ENSP00000389140
ENST00000412726	ENSP00000397322
ENST00000580024
ENST00000582875	ENSP00000463131
ENST00000579702
ENST00000579883
ENST00000579666
ENST00000578949	ENSP00000463766
ENST00000581559	ENSP00000463463
ENST00000581580	ENSP00000464582
ENST00000579349	ENSP00000464277
ENST00000580146
ENST00000584710
ENST00000579941	ENSP00000464292
ENST00000578080	ENSP00000463699
ENST00000582595
ENST00000577224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	53 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004888	transmembrane signaling receptor activity
GO:0005042	netrin receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001764	neuron migration
GO:0001975	response to amphetamine
GO:0006915	apoptotic process
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0021965	spinal cord ventral commissure morphogenesis
GO:0033563	dorsal/ventral axon guidance
GO:0033564	anterior/posterior axon guidance
GO:0038007	netrin-activated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0048671	negative regulation of collateral sprouting
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000171	negative regulation of dendrite development
GO:2001141	regulation of RNA biosynthetic process