Homo sapiens Gene: CYP4F11
Summary
InnateDB Gene IDBG-35111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4F11
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171903
Encoded Proteins
cytochrome P450, family 4, subfamily F, polypeptide 11
cytochrome P450, family 4, subfamily F, polypeptide 11
cytochrome P450, family 4, subfamily F, polypeptide 11
cytochrome P450, family 4, subfamily F, polypeptide 11
cytochrome P450, family 4, subfamily F, polypeptide 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15912367-15934867
Strand Reverse strand
Band p13.12
Transcripts
ENST00000248041 ENSP00000248041
ENST00000326742 ENSP00000319859
ENST00000402119 ENSP00000384588
ENST00000591841 ENSP00000476972
ENST00000620614 ENSP00000481243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006954 inflammatory response
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Cytochrome P450 - arranged by substrate type pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Fatty acids pathway
Metabolism pathway
Biological oxidations pathway
Eicosanoids pathway
Miscellaneous substrates pathway
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.187393
RefSeq NM_001128932 NM_021187
HUGO
OMIM
CCDS CCDS12337
HPRD 07101
IMGT
EMBL
GenPept
RNA Seq Atlas