Version 5.4
Homo sapiens Gene: CYP4F11
Summary
InnateDB Gene IDBG-35111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4F11
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171903
Encoded Proteins
IDBP-35113
cytochrome P450, family 4, subfamily F, polypeptide 11
IDBP-35115
cytochrome P450, family 4, subfamily F, polypeptide 11
IDBP-292869
cytochrome P450, family 4, subfamily F, polypeptide 11
IDBP-807378
cytochrome P450, family 4, subfamily F, polypeptide 11
IDBP-807381
cytochrome P450, family 4, subfamily F, polypeptide 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15912367-15934867
Strand Reverse strand
Band p13.12
Transcripts
ENST00000248041 ENSP00000248041
ENST00000326742 ENSP00000319859
ENST00000402119 ENSP00000384588
ENST00000591841 ENSP00000476972
ENST00000620614 ENSP00000481243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006954 inflammatory response
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_13814
Fatty acids pathway
REACT_13425
Miscellaneous substrates pathway
REACT_13645
Eicosanoids pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt Q9HBI6
TrEMBL V9GYP6
UniProt Splice Variant
Entrez Gene 57834
UniGene Hs.187393
RefSeq NM_021187 NM_001128932
HUGO HGNC:13265
OMIM 611517
CCDS CCDS12337
HPRD 07101
IMGT
EMBL AC005336 AC011517 AC020950 AF236085 BC016853
GenPept AAC27731 AAG15889 AAH16853
RNA Seq Atlas 57834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca