Version 5.4
Homo sapiens Gene: MYC
Summary
InnateDB Gene IDBG-35442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYC
Gene Name v-myc myelocytomatosis viral oncogene homolog (avian)
Synonyms bHLHe39; c-Myc; MRTL; MYCC
Species Homo sapiens
Ensembl Gene ENSG00000136997
Encoded Proteins
IDBP-35444
v-myc myelocytomatosis viral oncogene homolog (avian)
IDBP-35446
v-myc myelocytomatosis viral oncogene homolog (avian)
IDBP-482932
v-myc myelocytomatosis viral oncogene homolog (avian)
IDBP-483271
v-myc myelocytomatosis viral oncogene homolog (avian)
IDBP-480239
v-myc myelocytomatosis viral oncogene homolog (avian)
IDBP-808044
v-myc avian myelocytomatosis viral oncogene homolog
IDBP-808047
v-myc avian myelocytomatosis viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25049387
[Mus musculus] Pituitary hormone prolactin (Prl) constrains tumor-promoting liver inflammation by inhibiting Map3k1-dependent activation of Myc at the level of the trafasome.
Entrez Gene
Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt\'s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:127735434-127741434
Strand Forward strand
Band q24.21
Transcripts
ENST00000377970 ENSP00000367207
ENST00000259523 ENSP00000259523
ENST00000517291 ENSP00000429441
ENST00000524013 ENSP00000430235
ENST00000520751 ENSP00000430226
ENST00000621592 ENSP00000478887
ENST00000613283 ENSP00000479618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1433 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 1436 [view]
Protein-Protein 597 [view]
Protein-DNA 734 [view]
Protein-RNA 1 [view]
DNA-DNA 104 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0032403 protein complex binding
GO:0046983 protein dimerization activity
GO:0070491 repressing transcription factor binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0006112 energy reserve metabolic process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006879 cellular iron ion homeostasis
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010332 response to gamma radiation
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0015671 oxygen transport
GO:0032204 regulation of telomere maintenance
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034644 cellular response to UV
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0045087 innate immune response
GO:0045656 negative regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051276 chromosome organization
GO:0051782 negative regulation of cell division
GO:0060070 canonical Wnt signaling pathway
GO:0070848 response to growth factor
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001022 positive regulation of response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022346
View Gene Order
ENSBTAG00000008409
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_200799
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_899
S Phase pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_1783
G1/S Transition pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04010
MAPK signaling pathway pathway
hsa05216
Thyroid cancer pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa05222
Small cell lung cancer pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
cd40_pathway
CD40/CD40L signaling
ceramide_pathway
Ceramide signaling pathway
il2_1pathway
IL2-mediated signaling events
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ps1pathway
Presenilin action in Notch and Wnt signaling
myc_represspathway
Validated targets of C-MYC transcriptional repression
myc_activpathway
Validated targets of C-MYC transcriptional activation
lkb1_pathway
LKB1 signaling events
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ap1_pathway
AP-1 transcription factor network
p73pathway
p73 transcription factor network
cmyb_pathway
C-MYB transcription factor network
e2f_pathway
E2F transcription factor network
myc_pathway
C-MYC pathway
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
foxm1pathway
FOXM1 transcription factor network
il2_pi3kpathway
IL2 signaling events mediated by PI3K
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
telomerasepathway
Regulation of Telomerase
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL A0A024R9L7 B3CJ65 B4E1N7 H0YBG3 H0YBT0 Q6LBK7
UniProt Splice Variant
Entrez Gene 4609
UniGene Hs.202453 Hs.596284
RefSeq NM_002467
HUGO HGNC:7553
OMIM 190080
CCDS CCDS6359
HPRD 01818
IMGT
EMBL AC103819 AK303921 AK312883 AM287139 AM287141 AM287148 AM287150 AM287151 AM287157 AM287158 AM287159 AM287160 AM287163 AM287170 AM287171 AM287173 AM287174 AM287175 AM287179 AM287181 AM287186 AY214166 BC000141 BC000917 BC058901 BT019768 CH471060 D10493 K00534 K00535 K01905 K01906 K02276 L00057 L00058 M13929 V00568 X00196 X00198 X00364 X00676 X66258
GenPept AAA36340 AAA59880 AAA59881 AAA59882 AAA88092 AAH00141 AAH00917 AAH58901 AAO21131 AAV38573 ABW69847 BAA01374 BAA01375 BAG35731 BAG64849 CAA23831 CAA25015 CAA25106 CAA25288 CAA46984 CAL18308 CAL18311 CAL18321 CAL18324 CAL18333 CAL18335 CAL18337 CAL18341 CAL18350 CAL18352 CAL18356 CAL18358 CAL18360 CAL18365 CAL18369 CAL18377 CAL18619 CAL18623 EAW92098 EAW92100 EAW92101
RNA Seq Atlas 4609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca