Homo sapiens Gene: MAP2K3
InnateDB Gene IDBG-35553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K3
Gene Name mitogen-activated protein kinase kinase 3
Species Homo sapiens
Ensembl Gene ENSG00000034152
Encoded Proteins
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Activates MAPK14 (p38) MAP kinases
Entrez Gene
Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:21284672-21315240
Strand Forward strand
Band p11.2
ENST00000342679 ENSP00000345083
ENST00000361818 ENSP00000355081
ENST00000316920 ENSP00000319139
ENST00000395491 ENSP00000378869
ENST00000479129 ENSP00000463417
ENST00000483928 ENSP00000463202
ENST00000496046 ENSP00000464043
ENST00000529517 ENSP00000431203
ENST00000526076 ENSP00000434068
ENST00000527123 ENSP00000462178
ENST00000613338 ENSP00000478619
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 52 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042035 regulation of cytokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051403 stress-activated MAPK cascade
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016020 membrane
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
EGFR1 pathway
TGF_beta_Receptor pathway
IL1 pathway
Leptin pathway
TSH pathway
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
MAP kinase activation in TLR cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Cellular Senescence pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
activated TAK1 mediates p38 MAPK activation pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
MAPK signaling pathway pathway
Toll-like receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
GnRH signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Toxoplasmosis pathway
TGF-beta signaling pathway
BMP2 signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
The 41bb-dependent immune response [Biocarta view]
Toll-like receptor pathway [Biocarta view]
Human cytomegalovirus and map kinase pathways [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Signal transduction through il1r [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
Cellular roles of Anthrax toxin
TNF receptor signaling pathway
Signaling mediated by p38-gamma and p38-delta
Signaling events mediated by VEGFR1 and VEGFR2
Regulation of p38-alpha and p38-beta
p38 MAPK signaling pathway
UniProt Splice Variant
Entrez Gene 5606
RefSeq XM_003846747 NM_002756 NM_145109 XM_005256721 XM_005256722 XM_005256723
OMIM 602315
CCDS CCDS11218 CCDS11217
EMBL AC087294 CH471210
GenPept EAX02601 EAX02602
RNA Seq Atlas 100996792 5606