Homo sapiens Gene: SUGT1
Summary
InnateDB Gene IDBG-35701.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUGT1
Gene Name SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Synonyms SGT1;
Species Homo sapiens
Ensembl Gene ENSG00000165416
Encoded Proteins
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Positively regulates NOD1 activation
Bridges the HSP90 molecular chaperone system to the substrate-specific arm of SCF ubiquitin ligase complexes, suggesting a role in SCF assembly and regulation, and providing multiple complementary routes for ubiquitination of Hsp90 client proteins
Entrez Gene
Summary This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:52652709-52700909
Strand Forward strand
Band q14.3
Transcripts
ENST00000310528 ENSP00000308067
ENST00000343788 ENSP00000367208
ENST00000483074
ENST00000609175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
Experimentally validated
Total 102 [view]
Protein-Protein 97 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Inflammasomes pathway
The NLRP3 inflammasome pathway
KEGG
NOD-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y2Z0
TrEMBL
UniProt Splice Variant
Entrez Gene 10910
UniGene Hs.281902
RefSeq NM_001130912 NM_006704
HUGO HGNC:16987
OMIM 604098
CCDS CCDS45050 CCDS9436
HPRD
IMGT
EMBL AF132856 AJ344097 AL139089 AY271314 AY321358 BC000911 BT009798 CH471124
GenPept AAD30062 AAH00911 AAP88800 AAQ01749 AAQ76039 CAC51433 CAI17072 CAM23909 EAW52045
RNA Seq Atlas 10910