Homo sapiens Gene: LECT1
Summary
InnateDB Gene IDBG-35924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LECT1
Gene Name leukocyte cell derived chemotaxin 1
Synonyms BRICD3; CHM-I; CHM1; MYETS1;
Species Homo sapiens
Ensembl Gene ENSG00000136110
Encoded Proteins
leukocyte cell derived chemotaxin 1
leukocyte cell derived chemotaxin 1
leukocyte cell derived chemotaxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:52703264-52739812
Strand Reverse strand
Band q14.3
Transcripts
ENST00000377962 ENSP00000367198
ENST00000448904 ENSP00000388576
ENST00000431550 ENSP00000396035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001501 skeletal system development
GO:0001886 endothelial cell morphogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006029 proteoglycan metabolic process
GO:0016525 negative regulation of angiogenesis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0051216 cartilage development
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421391
RefSeq NM_001011705 NM_007015
HUGO
OMIM
CCDS CCDS45051 CCDS9437
HPRD 05511
IMGT
EMBL
GenPept
RNA Seq Atlas