Version 5.4
Homo sapiens Gene: LECT1
Summary
InnateDB Gene IDBG-35924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LECT1
Gene Name leukocyte cell derived chemotaxin 1
Synonyms BRICD3; CHM-I; CHM1; MYETS1
Species Homo sapiens
Ensembl Gene ENSG00000136110
Encoded Proteins
IDBP-35926
leukocyte cell derived chemotaxin 1
IDBP-369412
leukocyte cell derived chemotaxin 1
IDBP-369414
leukocyte cell derived chemotaxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:52703264-52739812
Strand Reverse strand
Band q14.3
Transcripts
ENST00000377962 ENSP00000367198
ENST00000448904 ENSP00000388576
ENST00000431550 ENSP00000396035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001501 skeletal system development
GO:0001886 endothelial cell morphogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006029 proteoglycan metabolic process
GO:0016525 negative regulation of angiogenesis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0051216 cartilage development
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022025
View Gene Order
ENSBTAG00000025502
Not yet available
Cross-References
SwissProt O75829
TrEMBL E9PKI9
UniProt Splice Variant
Entrez Gene 11061
UniGene Hs.421391
RefSeq NM_001011705 NM_007015
HUGO HGNC:17005
OMIM 605147
CCDS CCDS45051 CCDS9437
HPRD 05511
IMGT
EMBL AB005999 AB006000 AB021290 AF050147 AL139085 AL139089 BC025659 CR541910
GenPept AAC98971 AAH25659 BAA33443 BAA77384 BAA86262 CAG46708 CAI14108 CAI17074
RNA Seq Atlas 11061

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca