Version 5.4
Homo sapiens Gene: PPIP5K2
Summary
InnateDB Gene IDBG-35927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPIP5K2
Gene Name diphosphoinositol pentakisphosphate kinase 2
Synonyms HISPPD1; IP7K2; VIP2
Species Homo sapiens
Ensembl Gene ENSG00000145725
Encoded Proteins
IDBP-35929
diphosphoinositol pentakisphosphate kinase 2
IDBP-35931
diphosphoinositol pentakisphosphate kinase 2
IDBP-374483
diphosphoinositol pentakisphosphate kinase 2
IDBP-481412
diphosphoinositol pentakisphosphate kinase 2
IDBP-485196
diphosphoinositol pentakisphosphate kinase 2
IDBP-717620
IDBP-717500
IDBP-475163
diphosphoinositol pentakisphosphate kinase 2
IDBP-478737
diphosphoinositol pentakisphosphate kinase 2
IDBP-717570
IDBP-808692
diphosphoinositol pentakisphosphate kinase 2
IDBP-808700
diphosphoinositol pentakisphosphate kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:103120149-103212799
Strand Forward strand
Band q21.1
Transcripts
ENST00000358359 ENSP00000351126
ENST00000321521 ENSP00000313070
ENST00000414217 ENSP00000416016
ENST00000515845 ENSP00000421513
ENST00000507921 ENSP00000422525
ENST00000504275 ENSP00000465165
ENST00000502481 ENSP00000467529
ENST00000507310 ENSP00000424535
ENST00000509597 ENSP00000424948
ENST00000508935
ENST00000511724
ENST00000511022 ENSP00000467099
ENST00000510672
ENST00000504083
ENST00000613674 ENSP00000482907
ENST00000613907 ENSP00000480381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000832 inositol hexakisphosphate 5-kinase activity
GO:0003993 acid phosphatase activity
GO:0005524 ATP binding
GO:0033857 diphosphoinositol-pentakisphosphate kinase activity
GO:0052723 inositol hexakisphosphate 1-kinase activity
GO:0052724 inositol hexakisphosphate 3-kinase activity
Biological Process
GO:0006020 inositol metabolic process
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040648
View Gene Order
ENSBTAG00000001485
Not yet available
Pathways
NETPATH
REACTOME
REACT_150188
Synthesis of pyrophosphates in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RFG4
UniProt Splice Variant
Entrez Gene 23262
UniGene Hs.212046 Hs.630465
RefSeq NM_001276277 NM_001281471 NM_015216 XM_005271935 XM_006714578
HUGO HGNC:29035
OMIM 611648
CCDS CCDS34207 CCDS64212 CCDS75283
HPRD 13802
IMGT
EMBL AC008447 AC011362
GenPept
RNA Seq Atlas 23262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca