|Homo sapiens Gene: NOS2|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||nitric oxide synthase 2, inducible|
|Synonyms||HEP-NOS; INOS; NOS; NOS2A|
nitric oxide synthase 2, inducible
nitric oxide synthase 2, inducible
|Useful resources||Stemformatics EHFPI ImmGen|
NOS2 is a nitric oxide synthase (iNOS) protein and combined treatment with 1,25-dihydroxyvitamin D3 (1,25-D3) and IFN-gamma has been shown to synergistically enhance NO synthesis and NOS2 expression induced by Mycobacterium tuberculosis (MTB) or by its purified protein derivatives in human monocyte-derived macrophages.
NOS2 is an inducible nitric oxide (NO) synthase present in innate immune cells that produces NO in response to certain infections or upon stimulation with cytokines such as IFN-gamma and TNF. For optimal induction of NOS2 during Chlamydophila pneumoniae infection, the concerted action of the MyD88-dependent transcription factors NF-kappaB and AP-1 and of the MyD88-independent transcription factors phosphorylated STAT1 and IRF1 is required.
NOS2 (iNOS) and CALM1 (CaM) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to up-regulate the innate immune system involving macrophage activation.
Nitric oxide production by NOS2 promotes Listeria monocytogenes dissemination in the host. (Demonstrated in mice)
|InnateDB Annotation from Orthologs|
[Mus musculus] Nos2 (iNOS) and Calm1 (CaM) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to upregulate the innate immune system involving macrophage activation.
[Mus musculus] Nitric oxide production by Nos2 promotes Listeria monocytogenes dissemination in the host.
[Mus musculus] Inorganic polyphosphate suppresses Nos2 expression and nitric oxide release but not TNF release in LPS-activated macrophages
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 17:27756766-27800499|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Not yet available
Nitric oxide stimulates guanylate cyclase pathway
Platelet homeostasis pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Arginine and proline metabolism pathway
Small cell lung cancer pathway
Calcium signaling pathway pathway
Pathways in cancer pathway
Chagas disease (American trypanosomiasis) pathway
Arginine Proline metabolism pathway
IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
HIF-1-alpha transcription factor network
Signaling mediated by p38-alpha and p38-beta
|UniProt Splice Variant|
|EMBL||AB022318 AF068236 BC130283 BC144126 D26525 DQ060518 EU332854 L09210 L24553 S75615 S76479 U05810 U20141 U31511 X73029|
|GenPept||AAA36375 AAA56666 AAA59171 AAB49041 AAB60366 AAC19133 AAD14179 AAD14226 AAI30284 AAI44127 AAY43131 ABY87543 BAA05531 BAA37123 CAA51512|
|RNA Seq Atlas||4843|