Homo sapiens Gene: CCNA2
Summary
InnateDB Gene IDBG-36372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNA2
Gene Name cyclin A2
Synonyms CCN1; CCNA;
Species Homo sapiens
Ensembl Gene ENSG00000145386
Encoded Proteins
cyclin A2
cyclin A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:121816444-121823933
Strand Reverse strand
Band q27
Transcripts
ENST00000274026 ENSP00000274026
ENST00000618014 ENSP00000481380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 120 [view]
Protein-Protein 111 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007265 Ras protein signal transduction
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0031100 organ regeneration
GO:0032355 response to estradiol
GO:0033762 response to glucagon
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
BCR pathway
REACTOME
DNA Replication pathway
Cyclin A/B1 associated events during G2/M transition pathway
Cellular responses to stress pathway
Synthesis of DNA pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Removal of licensing factors from origins pathway
Cellular Senescence pathway
Cyclin E associated events during G1/S transition pathway
G0 and Early G1 pathway
G2/M Transition pathway
Switching of origins to a post-replicative state pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Mitotic G2-G2/M phases pathway
Regulation of DNA replication pathway
G2 Phase pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Regulation of retinoblastoma protein
ATF-2 transcription factor network
p53 pathway
p73 transcription factor network
E2F transcription factor network
Signaling events mediated by PRL
IL2 signaling events mediated by STAT5
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 890
UniGene
RefSeq NM_001237
HUGO HGNC:1578
OMIM 123835
CCDS CCDS3723
HPRD
IMGT
EMBL AC079341 AF518006 AK291931 BC104783 BC104787 CH471056 CR407692 X51688 X68303
GenPept AAI04784 AAI04788 AAM54042 AAY40969 BAF84620 CAA35986 CAA48375 CAG28620 EAX05246
RNA Seq Atlas 890