InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RASSF1

Summary

InnateDB Gene

IDBG-36632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASSF1

Gene Name

Ras association (RalGDS/AF-6) domain family member 1

Synonyms

123F2; NORE2A; RASSF1A; RDA32; REH3P21

Species

Homo sapiens

Ensembl Gene

ENSG00000068028

Encoded Proteins

IDBP-36634

Ras association (RalGDS/AF-6) domain family member 1

IDBP-36636

Ras association (RalGDS/AF-6) domain family member 1

IDBP-36642

Ras association (RalGDS/AF-6) domain family member 1

IDBP-240175

Ras association (RalGDS/AF-6) domain family member 1

IDBP-240177

Ras association (RalGDS/AF-6) domain family member 1

IDBP-586875

Ras association (RalGDS/AF-6) domain family member 1

IDBP-810807

Ras association (RalGDS/AF-6) domain family member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50329782-50340980

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000357043	ENSP00000349547
ENST00000359365	ENSP00000352323
ENST00000327761	ENSP00000333327
ENST00000395126	ENSP00000378558
ENST00000395117	ENSP00000378549
ENST00000482447	ENSP00000433000
ENST00000478619
ENST00000488024
ENST00000494145
ENST00000616212	ENSP00000482696

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	76 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0031398	positive regulation of protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0050821	protein stabilization
GO:0071157	negative regulation of cell cycle arrest

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000010067

View Gene Order

ENSBTAG00000020963

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05223

Non-small cell lung cancer pathway

hsa05219

Bladder cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

p53regulationpathway

p53 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.476270

RefSeq

NM_001206957 NM_007182 NM_170712 NM_170713 NM_170714

HUGO

OMIM

CCDS

CCDS2820 CCDS2821 CCDS2822 CCDS43096

HPRD

05470

IMGT

EMBL

GenPept

RNA Seq Atlas