Homo sapiens Gene: EIF2C2
Summary
InnateDB Gene IDBG-37096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2C2
Gene Name eukaryotic translation initiation factor 2C, 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123908
Encoded Proteins
eukaryotic translation initiation factor 2C, 2
eukaryotic translation initiation factor 2C, 2
eukaryotic translation initiation factor 2C, 2
eukaryotic translation initiation factor 2C, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:140531165-140635619
Strand Reverse strand
Band q24.3
Transcripts
ENST00000220592 ENSP00000220592
ENST00000519980 ENSP00000430176
ENST00000523609 ENSP00000430164
ENST00000520628
ENST00000520412
ENST00000519347
ENST00000521325
ENST00000517293
ENST00000524328 ENSP00000431056
ENST00000518019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 135 [view]
Protein-Protein 127 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0004521 endoribonuclease activity
GO:0005515 protein binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006379 mRNA cleavage
GO:0006412 translation
GO:0006413 translational initiation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009791 post-embryonic development
GO:0010467 gene expression
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045947 negative regulation of translational initiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0016020 membrane
GO:0016442 RISC complex
GO:0030529 ribonucleoprotein complex
GO:0035068 micro-ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Pre-NOTCH Expression and Processing pathway
MicroRNA (miRNA) biogenesis pathway
beta-catenin independent WNT signaling pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Small interfering RNA (siRNA) biogenesis pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Post-transcriptional silencing by small RNAs pathway
Transcriptional regulation by small RNAs pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Pre-NOTCH Transcription and Translation pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Signaling by NOTCH pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Gene Expression pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713705
RefSeq NM_001164623 NM_012154
HUGO
OMIM
CCDS CCDS55279 CCDS6380
HPRD 06943
IMGT
EMBL
GenPept
RNA Seq Atlas