Homo sapiens Gene: PTK2
Summary
InnateDB Gene IDBG-37147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK2
Gene Name PTK2 protein tyrosine kinase 2
Synonyms FADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71;
Species Homo sapiens
Ensembl Gene ENSG00000169398
Encoded Proteins
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PTK2 induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signalling pathway.
Entrez Gene
Summary This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:140657900-141002216
Strand Reverse strand
Band q24.3
Transcripts
ENST00000340930 ENSP00000341189
ENST00000395218 ENSP00000378644
ENST00000430260 ENSP00000403416
ENST00000522684 ENSP00000429911
ENST00000519654 ENSP00000429929
ENST00000519465 ENSP00000429170
ENST00000517887 ENSP00000429082
ENST00000521059 ENSP00000429474
ENST00000517712 ENSP00000430916
ENST00000523539 ENSP00000428492
ENST00000519993 ENSP00000428570
ENST00000519419 ENSP00000429129
ENST00000524202 ENSP00000429023
ENST00000521986 ENSP00000430603
ENST00000523435 ENSP00000430828
ENST00000522950 ENSP00000429437
ENST00000523805
ENST00000520460
ENST00000521985
ENST00000518173
ENST00000522424 ENSP00000427774
ENST00000521562 ENSP00000431106
ENST00000521250 ENSP00000427972
ENST00000523388 ENSP00000429702
ENST00000521981 ENSP00000428593
ENST00000521029 ENSP00000429958
ENST00000518509
ENST00000520917
ENST00000520151 ENSP00000428482
ENST00000523670 ENSP00000428380
ENST00000519024 ENSP00000428232
ENST00000523746
ENST00000510126
ENST00000523474
ENST00000519899
ENST00000519361
ENST00000520843
ENST00000521172
ENST00000524357 ENSP00000429001
ENST00000521791 ENSP00000427825
ENST00000523067 ENSP00000429895
ENST00000520828 ENSP00000427762
ENST00000520475 ENSP00000428792
ENST00000519881 ENSP00000430277
ENST00000520892 ENSP00000427904
ENST00000523803 ENSP00000429530
ENST00000521907 ENSP00000427795
ENST00000517453 ENSP00000430951
ENST00000520045 ENSP00000430044
ENST00000521395 ENSP00000429907
ENST00000523675
ENST00000521332 ENSP00000429409
ENST00000524040 ENSP00000430037
ENST00000523679 ENSP00000429028
ENST00000524257 ENSP00000431023
ENST00000523797
ENST00000519635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 166 [view]
Protein-Protein 165 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008432 JUN kinase binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001890 placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009790 embryo development
GO:0010594 regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030010 establishment of cell polarity
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0032319 regulation of Rho GTPase activity
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0038007 netrin-activated signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040023 establishment of nucleus localization
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043542 endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048870 cell motility
GO:0050771 negative regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
GO:0051893 regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL3 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSH pathway
Prolactin pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Apoptotic execution phase pathway
Developmental Biology pathway
Cell-Cell communication pathway
EPHB-mediated forward signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by VEGF pathway
Innate Immune System pathway
Signal regulatory protein (SIRP) family interactions pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Apoptosis pathway
Signal Transduction pathway
Netrin-1 signaling pathway
Integrin alphaIIb beta3 signaling pathway
Apoptotic cleavage of cellular proteins pathway
Immune System pathway
EPHA-mediated growth cone collapse pathway
VEGFA-VEGFR2 Pathway pathway
Platelet Aggregation (Plug Formation) pathway
DCC mediated attractive signaling pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
EPH-Ephrin signaling pathway
Netrin mediated repulsion signals pathway
Hemostasis pathway
KEGG
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Biocarta view]
Ucalpain and friends in cell spread [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Cell to cell adhesion signaling [Biocarta view]
Integrin signaling pathway [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
PID NCI
Nongenotropic Androgen signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Caspase Cascade in Apoptosis
LPA receptor mediated events
CXCR4-mediated signaling events
Netrin-mediated signaling events
Integrins in angiogenesis
Internalization of ErbB1
Nectin adhesion pathway
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPHB forward signaling
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
a4b7 Integrin signaling
Cross-References
SwissProt
TrEMBL B4DWJ1 E5RG80 E5RHD8 E5RHK7 E5RJQ2
UniProt Splice Variant
Entrez Gene 5747
UniGene Hs.395482 Hs.712239 Hs.735374 Hs.736231
RefSeq NM_001199649 NM_005607 NM_153831 XM_005251006 XM_005251007 XM_005251008 XM_005251010 XM_005251011 XM_005251014 XM_006716607
HUGO HGNC:9611
OMIM 600758
CCDS CCDS56557 CCDS6381
HPRD 02859
IMGT
EMBL AC067931 AC100860 AC105009 AC105235 AK301557
GenPept BAG63053
RNA Seq Atlas 5747