Homo sapiens Gene: PARD6A
Summary
InnateDB Gene IDBG-37154.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARD6A
Gene Name par-6 partitioning defective 6 homolog alpha (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102981
Encoded Proteins
par-6 partitioning defective 6 homolog alpha (C. elegans)
par-6 partitioning defective 6 homolog alpha (C. elegans)
par-6 family cell polarity regulator alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67660946-67662778
Strand Forward strand
Band q22.1
Transcripts
ENST00000219255 ENSP00000219255
ENST00000458121 ENSP00000392388
ENST00000602551 ENSP00000473257
ENST00000602727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017048 Rho GTPase binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0007049 cell cycle
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016032 viral process
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0045217 cell-cell junction maintenance
GO:0051301 cell division
GO:0070830 tight junction assembly
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0043234 protein complex
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
PCP/CE pathway pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Tight junction interactions pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Cell-Cell communication pathway
beta-catenin independent WNT signaling pathway
Cell junction organization pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Asymmetric localization of PCP proteins pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell-cell junction organization pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Endocytosis pathway
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CDC42 signaling events
TGF-beta receptor signaling
RhoA signaling pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL R4GMM2
UniProt Splice Variant
Entrez Gene 50855
UniGene
RefSeq NM_016948 NM_001037281 XM_006721193 XM_006721194
HUGO HGNC:15943
OMIM 607484
CCDS CCDS10843 CCDS45514
HPRD
IMGT
EMBL AC010530
GenPept
RNA Seq Atlas 50855