Homo sapiens Gene: CAV1
Summary
InnateDB Gene IDBG-37314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAV1
Gene Name caveolin 1, caveolae protein, 22kDa
Synonyms BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21;
Species Homo sapiens
Ensembl Gene ENSG00000105974
Encoded Proteins
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
caveolin 1, caveolae protein, 22kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CAV1 is an important component of the innate host immune response to the majority of non-cytotoxic strains of P. aeruginosa by promoting bacterial clearance during acute pneumonia and chronic colonization.
CAV1 is a scaffolding protein of caveolae that plays an important role in host defence and inflammation and CAV1 deficiency dampens Toll-like receptor 4 signalling through NOS3 (eNOS) activation.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cav1 is an important component of the innate host immune response to the majority of non-cytotoxic strains of P. aeruginosa by promoting bacterial clearance during acute pneumonia and chronic colonization.
[Mus musculus] The Akt1/Mir199a/Cav1 pathway is a regulator of innate immunity that is dysfunctional in cystic fibrosis macrophages contributing to lung hyper-inflammation.
Entrez Gene
Summary The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:116524785-116561184
Strand Forward strand
Band q31.2
Transcripts
ENST00000341049 ENSP00000339191
ENST00000393470 ENSP00000377113
ENST00000393468 ENSP00000377111
ENST00000393467 ENSP00000377110
ENST00000405348 ENSP00000384348
ENST00000451122 ENSP00000409541
ENST00000456473 ENSP00000389033
ENST00000489856
ENST00000614113 ENSP00000479447
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 213 [view]
Protein-Protein 208 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005113 patched binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0016504 peptidase activator activity
GO:0019899 enzyme binding
GO:0032947 protein complex scaffold
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0000188 inactivation of MAPK activity
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002026 regulation of the force of heart contraction
GO:0002931 response to ischemia
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0006641 triglyceride metabolic process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006940 regulation of smooth muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0007595 lactation
GO:0007596 blood coagulation
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0009267 cellular response to starvation
GO:0009968 negative regulation of signal transduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010952 positive regulation of peptidase activity
GO:0016032 viral process
GO:0016050 vesicle organization
GO:0019217 regulation of fatty acid metabolic process
GO:0019915 lipid storage
GO:0030193 regulation of blood coagulation
GO:0030301 cholesterol transport
GO:0030514 negative regulation of BMP signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0031295 T cell costimulation
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032507 maintenance of protein location in cell
GO:0032570 response to progesterone
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033484 nitric oxide homeostasis
GO:0042310 vasoconstriction
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632 cholesterol homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043627 response to estrogen
GO:0044281 small molecule metabolic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045907 positive regulation of vasoconstriction
GO:0046209 nitric oxide metabolic process
GO:0046426 negative regulation of JAK-STAT cascade
GO:0048550 negative regulation of pinocytosis
GO:0048554 positive regulation of metalloenzyme activity
GO:0050900 leukocyte migration
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051480 cytosolic calcium ion homeostasis
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0052547 regulation of peptidase activity
GO:0055074 calcium ion homeostasis
GO:0060056 mammary gland involution
GO:0070836 caveola assembly
GO:0071455 cellular response to hyperoxia
GO:0072584 caveolin-mediated endocytosis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:2000286 receptor internalization involved in canonical Wnt receptor signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0002080 acrosomal membrane
GO:0005622 intracellular
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005929 cilium
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030666 endocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
eNOS activation and regulation pathway
Signaling by Wnt pathway
Signaling by VEGF pathway
Metabolism of nitric oxide pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
VEGFR2 mediated vascular permeability pathway
Signal Transduction pathway
Basigin interactions pathway
NOSTRIN mediated eNOS trafficking pathway
TCF dependent signaling in response to WNT pathway
VEGFA-VEGFR2 Pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Lipid digestion, mobilization, and transport pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
Hemostasis pathway
eNOS activation pathway
KEGG
Endocytosis pathway
Focal adhesion pathway
Bacterial invasion of epithelial cells pathway
Viral myocarditis pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Corticosteroids and cardioprotection [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Integrin signaling pathway [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
TNF receptor signaling pathway
Signaling events mediated by PTP1B
Direct p53 effectors
ALK1 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
Canonical Wnt signaling pathway
TGF-beta receptor signaling
VEGFR1 specific signals
PDGFR-alpha signaling pathway
Insulin Pathway
Cross-References
SwissProt Q03135
TrEMBL A0A024R757 C9JKI3
UniProt Splice Variant
Entrez Gene 857
UniGene Hs.74034
RefSeq NM_001172896 NM_001172897 NM_001172895 NM_001753
HUGO HGNC:1527
OMIM 601047
CCDS CCDS55156 CCDS5767
HPRD 03028
IMGT
EMBL AC006159 AF095591 AF095592 AF095593 AF125348 AJ133269 BC009685 BC082246 BT007143 CH471070 Z18951
GenPept AAD23745 AAD34722 AAH09685 AAH82246 AAP35807 CAA79476 CAB63654 EAW83503 EAW83505
RNA Seq Atlas 857