Homo sapiens Gene: MET
Summary
InnateDB Gene IDBG-37371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MET
Gene Name met proto-oncogene (hepatocyte growth factor receptor)
Synonyms AUTS9; c-Met; HGFR; RCCP2;
Species Homo sapiens
Ensembl Gene ENSG00000105976
Encoded Proteins
met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene (hepatocyte growth factor receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:116672390-116798386
Strand Forward strand
Band q31.2
Transcripts
ENST00000318493 ENSP00000317272
ENST00000397752 ENSP00000380860
ENST00000456159 ENSP00000413857
ENST00000436117 ENSP00000410980
ENST00000422097 ENSP00000398776
ENST00000454623 ENSP00000398140
ENST00000495962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 144 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 144 [view]
Protein-Protein 138 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005008 hepatocyte growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001889 liver development
GO:0001890 placenta development
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008283 cell proliferation
GO:0010828 positive regulation of glucose transport
GO:0014812 muscle cell migration
GO:0014902 myotube differentiation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030534 adult behavior
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050918 positive chemotaxis
GO:0051450 myoblast proliferation
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526 semaphorin-plexin signaling pathway
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028 positive regulation of endothelial cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
REACTOME
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Semaphorin interactions pathway
Axon guidance pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Axon guidance pathway
Focal adhesion pathway
Adherens junction pathway
Bacterial invasion of epithelial cells pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Malaria pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Melanoma pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Regulation of retinoblastoma protein
Direct p53 effectors
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Signaling events mediated by TCPTP
Stabilization and expansion of the E-cadherin adherens junction
Syndecan-1-mediated signaling events
Arf6 signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL C9JKM5
UniProt Splice Variant
Entrez Gene 4233
UniGene Hs.132966 Hs.619431
RefSeq NM_001127500 NM_000245 XM_006715988 XM_006715991 XM_006715990 XM_006715989
HUGO HGNC:7029
OMIM 164860
CCDS CCDS47689 CCDS43636
HPRD 01280
IMGT
EMBL AC002080 AC002543 AC004416
GenPept
RNA Seq Atlas 4233