Version 5.4
Homo sapiens Gene: FLOT2
Summary
InnateDB Gene IDBG-37810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLOT2
Gene Name flotillin 2
Synonyms ECS-1; ECS1; ESA; ESA1; M17S1
Species Homo sapiens
Ensembl Gene ENSG00000132589
Encoded Proteins
IDBP-240626
flotillin 2
IDBP-240628
flotillin 2
IDBP-760752
IDBP-763570
IDBP-758829
IDBP-764701
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28879335-28897679
Strand Reverse strand
Band q11.2
Transcripts
ENST00000394908 ENSP00000378368
ENST00000394906 ENSP00000378366
ENST00000465427 ENSP00000465819
ENST00000584569
ENST00000586827 ENSP00000465022
ENST00000580805 ENSP00000463304
ENST00000582174
ENST00000577789
ENST00000580313
ENST00000593158
ENST00000581509
ENST00000585169 ENSP00000463503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 51 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0007155 cell adhesion
GO:0008544 epidermis development
GO:0010629 negative regulation of gene expression
GO:0050821 protein stabilization
GO:0090002 establishment of protein localization to plasma membrane
GO:1902992 negative regulation of amyloid precursor protein catabolic process
Cellular Component
GO:0002080 acrosomal membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016600 flotillin complex
GO:0030139 endocytic vesicle
GO:0031982 vesicle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061981
View Gene Order
ENSBTAG00000010073
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514038 Hs.609817
RefSeq NM_004475 XM_005257950 XM_005257952 XM_005257953
HUGO
OMIM
CCDS CCDS11245
HPRD 00580
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca