Homo sapiens Gene: RSPO4
Summary
InnateDB Gene IDBG-38791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSPO4
Gene Name R-spondin 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101282
Encoded Proteins
R-spondin 4
R-spondin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:958452-1002264
Strand Reverse strand
Band p13
Transcripts
ENST00000217260 ENSP00000217260
ENST00000400634 ENSP00000383475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
regulation of FZD by ubiquitination pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q2I0M5
TrEMBL
UniProt Splice Variant
Entrez Gene 343637
UniGene Hs.444980
RefSeq NM_001040007 NM_001029871
HUGO HGNC:16175
OMIM 610573
CCDS CCDS42845 CCDS42846
HPRD
IMGT
EMBL AK122609 AL050325 DQ355152
GenPept ABC75877 CAB65783 CAM28322
RNA Seq Atlas 343637