Homo sapiens Gene: BAP1
Summary
InnateDB Gene IDBG-38830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAP1
Gene Name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Synonyms HUCEP-13; UCHL2;
Species Homo sapiens
Ensembl Gene ENSG00000163930
Encoded Proteins
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq, Jul 2008]
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52401013-52410350
Strand Reverse strand
Band p21.1
Transcripts
ENST00000296288 ENSP00000296288
ENST00000460680 ENSP00000417132
ENST00000469613 ENSP00000418320
ENST00000478368 ENSP00000420647
ENST00000466093
ENST00000490804
ENST00000471532
ENST00000483984
ENST00000490917 ENSP00000419709
ENST00000470173 ENSP00000417776
ENST00000615113 ENSP00000482839
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0001558 regulation of cell growth
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008285 negative regulation of cell proliferation
GO:0016579 protein deubiquitination
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0051726 regulation of cell cycle
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035517 PR-DUB complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.106674 Hs.622728
RefSeq NM_004656
HUGO
OMIM
CCDS CCDS2853
HPRD 04366
IMGT
EMBL
GenPept
RNA Seq Atlas