Homo sapiens Gene: CD63
Summary
InnateDB Gene IDBG-38974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD63
Gene Name CD63 molecule
Synonyms LAMP-3; ME491; MLA1; OMA81H; TSPAN30;
Species Homo sapiens
Ensembl Gene ENSG00000135404
Encoded Proteins
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
CD63 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Forms a complex with ELANE (neutrophil elastase 2) and plays a role in the targeting of ELANE to primary granules in neutrophils
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55725323-55729707
Strand Reverse strand
Band q13.2
Transcripts
ENST00000257857 ENSP00000257857
ENST00000420846 ENSP00000393502
ENST00000548898 ENSP00000447938
ENST00000548117
ENST00000552067 ENSP00000449684
ENST00000548160 ENSP00000449654
ENST00000546939 ENSP00000447356
ENST00000552692 ENSP00000449337
ENST00000549117 ENSP00000447730
ENST00000550050 ENSP00000449435
ENST00000552754 ENSP00000446807
ENST00000550776 ENSP00000448091
ENST00000555199
ENST00000552164 ENSP00000449281
ENST00000551173 ENSP00000446752
ENST00000546457 ENSP00000450191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0002576 platelet degranulation
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0034613 cellular protein localization
GO:0035646 endosome to melanosome transport
GO:0043473 pigmentation
GO:0045087 innate immune response (InnateDB)
GO:0048757 pigment granule maturation
GO:0050931 pigment cell differentiation
GO:1900746 regulation of vascular endothelial growth factor signaling pathway
GO:2000680 regulation of rubidium ion transport
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031088 platelet dense granule membrane
GO:0031226 intrinsic component of plasma membrane
GO:0031902 late endosome membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0097487 multivesicular body, internal vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613137
RefSeq NM_001257389 NM_001257390 NM_001257391 NM_001257392 NM_001257400 NM_001257401 NM_001267698 NM_001780
HUGO
OMIM
CCDS CCDS58242 CCDS58243 CCDS8890
HPRD 01121
IMGT
EMBL
GenPept
RNA Seq Atlas