Version 5.4
Homo sapiens Gene: GDF11
Summary
InnateDB Gene IDBG-39057.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDF11
Gene Name growth differentiation factor 11
Synonyms BMP-11; BMP11
Species Homo sapiens
Ensembl Gene ENSG00000135414
Encoded Proteins
IDBP-39059
growth differentiation factor 11
IDBP-600714
growth differentiation factor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55743280-55757278
Strand Forward strand
Band q13.2
Transcripts
ENST00000257868 ENSP00000257868
ENST00000546799 ENSP00000448390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001501 skeletal system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0007399 nervous system development
GO:0007498 mesoderm development
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0021512 spinal cord anterior/posterior patterning
GO:0031016 pancreas development
GO:0040007 growth
GO:0045596 negative regulation of cell differentiation
GO:0048469 cell maturation
GO:0048593 camera-type eye morphogenesis
GO:0060021 palate development
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025352
View Gene Order
ENSBTAG00000007417
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt O95390
TrEMBL A0A024RB20
UniProt Splice Variant
Entrez Gene 10220
UniGene Hs.600883 Hs.713829 Hs.719434
RefSeq NM_005811 XM_006719193 XM_006719194
HUGO HGNC:4216
OMIM 603936
CCDS CCDS8891
HPRD
IMGT
EMBL AF028333 AF028334 AF100907 CH471054
GenPept AAC72852 AAF21630 AAF21631 EAW96830 EAW96831
RNA Seq Atlas 10220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca