Homo sapiens Gene: NFATC4
Summary
InnateDB Gene IDBG-3927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFATC4
Gene Name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Synonyms NF-AT3; NF-ATC4; NFAT3;
Species Homo sapiens
Ensembl Gene ENSG00000100968
Encoded Proteins
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NFATC4 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nfatc4 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages.
Entrez Gene
Summary The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Oct 2008]
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24365673-24379604
Strand Forward strand
Band q12
Transcripts
ENST00000250373 ENSP00000250373
ENST00000440487
ENST00000413692 ENSP00000388910
ENST00000422617 ENSP00000396788
ENST00000424781 ENSP00000388668
ENST00000554591 ENSP00000452039
ENST00000556957
ENST00000555590 ENSP00000451224
ENST00000554966 ENSP00000450644
ENST00000539237 ENSP00000439350
ENST00000556279 ENSP00000452270
ENST00000553469 ENSP00000451502
ENST00000554050 ENSP00000451151
ENST00000554655
ENST00000554903 ENSP00000451853
ENST00000554779 ENSP00000451992
ENST00000557028
ENST00000553708 ENSP00000450590
ENST00000557674 ENSP00000452352
ENST00000553879 ENSP00000452349
ENST00000554344 ENSP00000450469
ENST00000554661 ENSP00000450733
ENST00000556169 ENSP00000451454
ENST00000557451 ENSP00000451284
ENST00000555453 ENSP00000450686
ENST00000556302
ENST00000554473 ENSP00000450810
ENST00000556759 ENSP00000451183
ENST00000555167 ENSP00000451395
ENST00000557767 ENSP00000451496
ENST00000555393 ENSP00000451801
ENST00000555802 ENSP00000451590
ENST00000555821
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042975 peroxisome proliferator activated receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001569 patterning of blood vessels
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007507 heart development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034644 cellular response to UV
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045333 cellular respiration
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0051145 smooth muscle cell differentiation
GO:0055001 muscle cell development
GO:0071285 cellular response to lithium ion
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Wnt signaling pathway pathway
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
ErbB2/ErbB3 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.77810
RefSeq NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_004554 XM_006720153
HUGO
OMIM
CCDS CCDS45089 CCDS55909 CCDS55910 CCDS55911 CCDS73625 CCDS9629
HPRD 09096
IMGT
EMBL
GenPept
RNA Seq Atlas