Homo sapiens Gene: LMNB1
Summary
InnateDB Gene IDBG-39467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMNB1
Gene Name lamin B1
Synonyms ADLD; LMN; LMN2; LMNB;
Species Homo sapiens
Ensembl Gene ENSG00000113368
Encoded Proteins
lamin B1
lamin B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:126776623-126837020
Strand Forward strand
Band q23.2
Transcripts
ENST00000261366 ENSP00000261366
ENST00000395354 ENSP00000378761
ENST00000460265
ENST00000504788
ENST00000472034
ENST00000492190
ENST00000463908
ENST00000494185
ENST00000512460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 68 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0043274 phospholipase binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005638 lamin filament
GO:0005654 nucleoplasm
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TSLP pathway
REACTOME
Apoptotic execution phase pathway
Cellular responses to stress pathway
Initiation of Nuclear Envelope Reformation pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Meiotic synapsis pathway
Apoptosis pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Apoptotic cleavage of cellular proteins pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Mitotic Prophase pathway
Nuclear Envelope Reassembly pathway
Breakdown of the nuclear lamina pathway
Cell Cycle, Mitotic pathway
Meiosis pathway
Depolymerisation of the Nuclear Lamina pathway
Nuclear Envelope Breakdown pathway
Clearance of Nuclear Envelope Membranes from Chromatin pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.89497
RefSeq NM_001198557 NM_005573
HUGO
OMIM
CCDS CCDS4140
HPRD 01036
IMGT
EMBL
GenPept
RNA Seq Atlas