Version 5.4
Homo sapiens Gene: GNL3
Summary
InnateDB Gene IDBG-39482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNL3
Gene Name guanine nucleotide binding protein-like 3 (nucleolar)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163938
Encoded Proteins
IDBP-240832
guanine nucleotide binding protein-like 3 (nucleolar)
IDBP-379583
guanine nucleotide binding protein-like 3 (nucleolar)
IDBP-480293
guanine nucleotide binding protein-like 3 (nucleolar)
IDBP-473679
guanine nucleotide binding protein-like 3 (nucleolar)
IDBP-483907
guanine nucleotide binding protein-like 3 (nucleolar)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52681156-52694492
Strand Forward strand
Band p21.1
Transcripts
ENST00000394799 ENSP00000378278
ENST00000418458 ENSP00000395772
ENST00000479230 ENSP00000419734
ENST00000468146
ENST00000468885
ENST00000462550
ENST00000492349 ENSP00000420345
ENST00000496254
ENST00000474423 ENSP00000419895
ENST00000460073
ENST00000484022
ENST00000497356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 74 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0008283 cell proliferation
GO:0042127 regulation of cell proliferation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042354
View Gene Order
ENSBTAG00000014549
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.313544 Hs.600457
RefSeq NM_014366 NM_206825 NM_206826
HUGO
OMIM
CCDS CCDS2861 CCDS43100
HPRD 06419
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca