Version 5.4
Homo sapiens Gene: CDK2
Summary
InnateDB Gene IDBG-39545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK2
Gene Name cyclin-dependent kinase 2
Synonyms CDKN2; p33(CDK2)
Species Homo sapiens
Ensembl Gene ENSG00000123374
Encoded Proteins
IDBP-39547
cyclin-dependent kinase 2
IDBP-39549
cyclin-dependent kinase 2
IDBP-377440
cyclin-dependent kinase 2
IDBP-586314
cyclin-dependent kinase 2
IDBP-598070
cyclin-dependent kinase 2
IDBP-591343
cyclin-dependent kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55966769-55972784
Strand Forward strand
Band q13.2
Transcripts
ENST00000266970 ENSP00000266970
ENST00000354056 ENSP00000243067
ENST00000440311 ENSP00000393605
ENST00000556464
ENST00000555408 ENSP00000450983
ENST00000553376 ENSP00000452514
ENST00000555357 ENSP00000452138
ENST00000554619
ENST00000556276
ENST00000556656
ENST00000556146
ENST00000554545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 655 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 655 [view]
Protein-Protein 646 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
GO:0035173 histone kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000085 mitotic G2 phase
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006813 potassium ion transport
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0007265 Ras protein signal transduction
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0016572 histone phosphorylation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032298 positive regulation of DNA-dependent DNA replication initiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051298 centrosome duplication
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060968 regulation of gene silencing
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000781 chromosome, telomeric region
GO:0000793 condensed chromosome
GO:0000805 X chromosome
GO:0000806 Y chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005813 centrosome
GO:0005829 cytosol
GO:0015030 Cajal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025358
View Gene Order
ENSBTAG00000004021
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_5
ID pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_23
TSH pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1221
CDK-mediated phosphorylation and removal of Cdc6 pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_111214
G0 and Early G1 pathway
REACT_308
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_1915
G2 Phase pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_27271
Meiotic recombination pathway
REACT_383
DNA Replication pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_2203
G2/M Transition pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_111183
Meiosis pathway
REACT_829
Regulation of DNA replication pathway
REACT_604
Hemostasis pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa04115
p53 signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
il2_1pathway
IL2-mediated signaling events
mtor_4pathway
mTOR signaling pathway
foxopathway
FoxO family signaling
p53regulationpathway
p53 pathway
p73pathway
p73 transcription factor network
e2f_pathway
E2F transcription factor network
prlsignalingeventspathway
Signaling events mediated by PRL
bard1pathway
BARD1 signaling events
atr_pathway
ATR signaling pathway
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.19192 Hs.717547
RefSeq NM_001798 NM_052827
HUGO
OMIM
CCDS CCDS8898 CCDS8899
HPRD 00310
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca