Homo sapiens Gene: CDK2
InnateDB Gene IDBG-39545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK2
Gene Name cyclin-dependent kinase 2
Synonyms CDKN2; p33(CDK2)
Species Homo sapiens
Ensembl Gene ENSG00000123374
Encoded Proteins
cyclin-dependent kinase 2
cyclin-dependent kinase 2
cyclin-dependent kinase 2
cyclin-dependent kinase 2
cyclin-dependent kinase 2
cyclin-dependent kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55966769-55972784
Strand Forward strand
Band q13.2
ENST00000266970 ENSP00000266970
ENST00000354056 ENSP00000243067
ENST00000440311 ENSP00000393605
ENST00000555408 ENSP00000450983
ENST00000553376 ENSP00000452514
ENST00000555357 ENSP00000452138
Number of Interactions This gene and/or its encoded proteins are associated with 655 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 655 [view]
Protein-Protein 646 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
GO:0035173 histone kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000085 mitotic G2 phase
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006813 potassium ion transport
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0007265 Ras protein signal transduction
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0016572 histone phosphorylation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032298 positive regulation of DNA-dependent DNA replication initiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051298 centrosome duplication
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060968 regulation of gene silencing
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000781 chromosome, telomeric region
GO:0000793 condensed chromosome
GO:0000805 X chromosome
GO:0000806 Y chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005813 centrosome
GO:0005829 cytosol
GO:0015030 Cajal body
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
BCR pathway
IL2 pathway
TSH pathway
Oncostatin_M pathway
Activation of ATR in response to replication stress pathway
p53-Dependent G1 DNA Damage Response pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Activation of the pre-replicative complex pathway
G0 and Early G1 pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cyclin E associated events during G1/S transition pathway
G2 Phase pathway
Cyclin A/B1 associated events during G2/M transition pathway
Factors involved in megakaryocyte development and platelet production pathway
Meiotic recombination pathway
DNA Replication pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Synthesis of DNA pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
G2/M Transition pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
G1/S DNA Damage Checkpoints pathway
Mitotic G2-G2/M phases pathway
Meiosis pathway
Regulation of DNA replication pathway
Hemostasis pathway
Cell Cycle Checkpoints pathway
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
Regulation of retinoblastoma protein
IL2-mediated signaling events
mTOR signaling pathway
FoxO family signaling
p53 pathway
p73 transcription factor network
E2F transcription factor network
Signaling events mediated by PRL
BARD1 signaling events
ATR signaling pathway
FOXM1 transcription factor network
UniProt Splice Variant
Entrez Gene
UniGene Hs.19192 Hs.717547
RefSeq NM_001798 NM_052827
HPRD 00310
RNA Seq Atlas