Homo sapiens Gene: MEGF10
Summary
InnateDB Gene IDBG-39569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEGF10
Gene Name multiple EGF-like-domains 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145794
Encoded Proteins
multiple EGF-like-domains 10
multiple EGF-like-domains 10
multiple EGF-like-domains 10
multiple EGF-like-domains 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:127290831-127465737
Strand Forward strand
Band q23.2
Transcripts
ENST00000274473 ENSP00000274473
ENST00000418761 ENSP00000416284
ENST00000503335 ENSP00000423354
ENST00000508365 ENSP00000423195
ENST00000515002
ENST00000506709
ENST00000510513
ENST00000510828
ENST00000507158
ENST00000515622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0014719 satellite cell activation
GO:0014816 satellite cell differentiation
GO:0014841 satellite cell proliferation
GO:0034109 homotypic cell-cell adhesion
GO:0043654 recognition of apoptotic cell
GO:0048641 regulation of skeletal muscle tissue development
GO:0051147 regulation of muscle cell differentiation
GO:0055001 muscle cell development
Cellular Component
GO:0001891 phagocytic cup
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q96KG7
TrEMBL
UniProt Splice Variant
Entrez Gene 84466
UniGene Hs.438709
RefSeq NM_032446 NM_001256545 XM_006714722
HUGO HGNC:29634
OMIM 612453
CCDS CCDS4142
HPRD 14384
IMGT
EMBL AB058676 BC020198 BC152478 CH471062 CR749437
GenPept AAH20198 AAI52479 BAB47409 CAH18275 EAW62406
RNA Seq Atlas 84466