Version 5.4
Homo sapiens Gene: AARS
Summary
InnateDB Gene IDBG-39794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AARS
Gene Name alanyl-tRNA synthetase
Synonyms CMT2N
Species Homo sapiens
Ensembl Gene ENSG00000090861
Encoded Proteins
IDBP-39796
alanyl-tRNA synthetase
IDBP-750096
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41%% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70252295-70289543
Strand Reverse strand
Band q22.1
Transcripts
ENST00000261772 ENSP00000261772
ENST00000569825
ENST00000564359
ENST00000569790
ENST00000566969
ENST00000567490
ENST00000565361 ENSP00000455360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016597 amino acid binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
Biological Process
GO:0001942 hair follicle development
GO:0006400 tRNA modification
GO:0006418 tRNA aminoacylation for protein translation
GO:0006419 alanyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
GO:0006457 protein folding
GO:0008033 tRNA processing
GO:0008219 cell death
GO:0010467 gene expression
GO:0021680 cerebellar Purkinje cell layer development
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034620 cellular response to unfolded protein
GO:0043039 tRNA aminoacylation
GO:0043200 response to amino acid
GO:0043524 negative regulation of neuron apoptotic process
GO:0043588 skin development
GO:0050885 neuromuscular process controlling balance
GO:0050905 neuromuscular process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031960
View Gene Order
ENSBTAG00000019810
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt P49588
TrEMBL
UniProt Splice Variant
Entrez Gene 16
UniGene Hs.315137
RefSeq NM_001605 XM_006721153
HUGO HGNC:20
OMIM 601065
CCDS CCDS32474
HPRD
IMGT
EMBL AC012184 AK222824 BC011451 CH471241 D32050
GenPept AAH11451 BAA06808 BAD96544 EAW51839
RNA Seq Atlas 16

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca