Homo sapiens Gene: PA2G4
Summary
InnateDB Gene IDBG-39891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PA2G4
Gene Name proliferation-associated 2G4, 38kDa
Synonyms EBP1; HG4-1; p38-2G4;
Species Homo sapiens
Ensembl Gene ENSG00000170515
Encoded Proteins
proliferation-associated 2G4, 38kDa
proliferation-associated 2G4, 38kDa
proliferation-associated 2G4, 38kDa
proliferation-associated 2G4, 38kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56104319-56113907
Strand Forward strand
Band q13.2
Transcripts
ENST00000303305 ENSP00000302886
ENST00000552766 ENSP00000448557
ENST00000553057 ENSP00000447615
ENST00000551061 ENSP00000447389
ENST00000550166
ENST00000552528
ENST00000552266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
Experimentally validated
Total 98 [view]
Protein-Protein 88 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0007050 cell cycle arrest
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt Q9UQ80
TrEMBL A0A024RB85 A8K6Y1 F8VR77 F8VZ69 F8W0A3 Q6PIN5
UniProt Splice Variant
Entrez Gene 5036
UniGene Hs.524498
RefSeq NM_006191
HUGO HGNC:8550
OMIM 602145
CCDS CCDS8902
HPRD
IMGT
EMBL AC034102 AF104668 AF104669 AF104670 AK291796 BC001951 BC007561 BC032111 BC069786 BC072007 CH471054 U59435 U87954
GenPept AAB91536 AAD00646 AAD05561 AAH01951 AAH07561 AAH32111 AAH69786 AAH72007 BAF84485 EAW96884 EAW96885
RNA Seq Atlas 5036