Homo sapiens Gene: MYL6
Summary
InnateDB Gene IDBG-40095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL6
Gene Name myosin, light chain 6, alkali, smooth muscle and non-muscle
Synonyms ESMLC; LC17; LC17-GI; LC17-NM; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM;
Species Homo sapiens
Ensembl Gene ENSG00000092841
Encoded Proteins
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light chain 6, alkali, smooth muscle and non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56158161-56163496
Strand Forward strand
Band q13.2
Transcripts
ENST00000348108 ENSP00000301540
ENST00000293422 ENSP00000293422
ENST00000550697 ENSP00000446955
ENST00000548580 ENSP00000446640
ENST00000550184
ENST00000552297
ENST00000549017 ENSP00000449086
ENST00000547703
ENST00000549566 ENSP00000446709
ENST00000536128 ENSP00000441750
ENST00000547649 ENSP00000446714
ENST00000548725
ENST00000547408 ENSP00000446721
ENST00000551589 ENSP00000446687
ENST00000550639
ENST00000546630
ENST00000549392 ENSP00000450116
ENST00000548400 ENSP00000448859
ENST00000548293 ENSP00000448101
ENST00000546845 ENSP00000448457
ENST00000551954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0030898 actin-dependent ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0007411 axon guidance
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0030049 muscle filament sliding
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0016459 myosin complex
GO:0016461 unconventional myosin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
Smooth Muscle Contraction pathway
EPHA-mediated growth cone collapse pathway
EPH-Ephrin signaling pathway
Muscle contraction pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8VXL3
UniProt Splice Variant
Entrez Gene 4637
UniGene Hs.733233
RefSeq NM_021019 NM_079423
HUGO HGNC:7587
OMIM 609931
CCDS CCDS8906 CCDS31834
HPRD 17618
IMGT
EMBL AC034102 AC073896
GenPept
RNA Seq Atlas 4637