Version 5.4
Homo sapiens Gene: SMARCC2
Summary
InnateDB Gene IDBG-40152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCC2
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms BAF170; CRACC2; Rsc8
Species Homo sapiens
Ensembl Gene ENSG00000139613
Encoded Proteins
IDBP-40154
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-40156
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-242402
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-585068
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-598087
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
IDBP-602105
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56162983-56189567
Strand Reverse strand
Band q13.2
Transcripts
ENST00000267064 ENSP00000267064
ENST00000347471 ENSP00000302919
ENST00000394023 ENSP00000377591
ENST00000550164 ENSP00000449396
ENST00000552674 ENSP00000447680
ENST00000549209
ENST00000548130
ENST00000552931
ENST00000552566
ENST00000549757
ENST00000550859
ENST00000550519 ENSP00000449429
ENST00000550150
ENST00000552627
ENST00000547356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 127 [view]
Protein-Protein 125 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0043044 ATP-dependent chromatin remodeling
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0017053 transcriptional repressor complex
GO:0043234 protein complex
GO:0071564 npBAF complex
GO:0071565 nBAF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025369
View Gene Order
ENSBTAG00000014697
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.236030 Hs.733233
RefSeq NM_001130420 NM_003075 NM_139067 XM_005269101 XM_005269102 XM_005269103 XM_005269104
HUGO
OMIM
CCDS CCDS55835 CCDS8907 CCDS8908
HPRD 03437
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca