Homo sapiens Gene: CCL7
Summary
InnateDB Gene IDBG-40580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL7
Gene Name chemokine (C-C motif) ligand 7
Synonyms FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7;
Species Homo sapiens
Ensembl Gene ENSG00000108688
Encoded Proteins
chemokine (C-C motif) ligand 7
chemokine (C-C motif) ligand 7
chemokine (C-C motif) ligand 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34270221-34272242
Strand Forward strand
Band q12
Transcripts
ENST00000378569 ENSP00000367832
ENST00000394630 ENSP00000378126
ENST00000394627 ENSP00000378124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 19 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0031726 CCR1 chemokine receptor binding
GO:0031727 CCR2 chemokine receptor binding
Biological Process
GO:0002548 monocyte chemotaxis
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008360 regulation of cell shape
GO:0010332 response to gamma radiation
GO:0030335 positive regulation of cell migration
GO:0048245 eosinophil chemotaxis
GO:0060326 cell chemotaxis
GO:0071361 cellular response to ethanol
GO:2000503 positive regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P80098
TrEMBL A8MVH1 A8MX17 Q7Z7Q8
UniProt Splice Variant
Entrez Gene 6354
UniGene
RefSeq NM_006273
HUGO HGNC:10634
OMIM 158106
CCDS CCDS11278
HPRD
IMGT
EMBL AC005549 AF043338 BC092436 BC112258 BC112260 CH471147 X71087 X72308 X72309
GenPept AAC03538 AAH92436 AAI12259 AAI12261 CAA50405 CAA50406 CAA50407 CAA51055 CAB59723 EAW80210
RNA Seq Atlas 6354