Version 5.4
Homo sapiens Gene: ARPC4
Summary
InnateDB Gene IDBG-407641.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC4
Gene Name actin related protein 2/3 complex, subunit 4, 20kDa
Synonyms ARC20; P20-ARC
Species Homo sapiens
Ensembl Gene ENSG00000241553
Encoded Proteins
IDBP-235751
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-361899
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-361902
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-361903
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-361906
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-361935
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-585073
actin related protein 2/3 complex, subunit 4, 20kDa
IDBP-808459
actin related protein 2/3 complex, subunit 4, 20kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:9792495-9807726
Strand Forward strand
Band p25.3
Transcripts
ENST00000397261 ENSP00000380431
ENST00000424442 ENSP00000412284
ENST00000418163 ENSP00000402163
ENST00000417500 ENSP00000414751
ENST00000440787 ENSP00000395085
ENST00000433034 ENSP00000388169
ENST00000498623 ENSP00000432235
ENST00000479956
ENST00000467289
ENST00000485273 ENSP00000473435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030674 protein binding, bridging
GO:0051015 actin filament binding
Biological Process
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045010 actin nucleation
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079426
View Gene Order
ENSBTAG00000007964
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001024959 NM_001024960 NM_001198780 NM_005718 NM_001198793
HUGO
OMIM
CCDS CCDS43047 CCDS46743 CCDS56238 CCDS56237
HPRD 10368
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca