Homo sapiens Gene: ARPC4
Summary
InnateDB Gene IDBG-407641.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC4
Gene Name actin related protein 2/3 complex, subunit 4, 20kDa
Synonyms ARC20; P20-ARC;
Species Homo sapiens
Ensembl Gene ENSG00000241553
Encoded Proteins
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:9792495-9807726
Strand Forward strand
Band p25.3
Transcripts
ENST00000397261 ENSP00000380431
ENST00000424442 ENSP00000412284
ENST00000418163 ENSP00000402163
ENST00000417500 ENSP00000414751
ENST00000440787 ENSP00000395085
ENST00000433034 ENSP00000388169
ENST00000498623 ENSP00000432235
ENST00000479956
ENST00000467289
ENST00000485273 ENSP00000473435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030674 protein binding, bridging
GO:0051015 actin filament binding
Biological Process
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045010 actin nucleation
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
KEGG
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
INOH
PID BIOCARTA
Y branching of actin filaments [Biocarta view]
How does salmonella hijack a cell [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
PID NCI
ErbB1 downstream signaling
RAC1 signaling pathway
CDC42 signaling events
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL F8WE39
UniProt Splice Variant
Entrez Gene 100526693
UniGene
RefSeq NM_005718 NM_001024960 NM_001024959 NM_001198780 NM_001198793
HUGO HGNC:38830
OMIM
CCDS CCDS43047 CCDS46743 CCDS56238 CCDS56237
HPRD 10368
IMGT
EMBL AC022382
GenPept
RNA Seq Atlas 100526693