Homo sapiens Gene: ARPC4 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-407641.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ARPC4 | ||||||||||||||||||||||
Gene Name | actin related protein 2/3 complex, subunit 4, 20kDa | ||||||||||||||||||||||
Synonyms | ARC20; P20-ARC | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000241553 | ||||||||||||||||||||||
Encoded Proteins |
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
actin related protein 2/3 complex, subunit 4, 20kDa
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 3:9792495-9807726 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p25.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
|
||||||||||||||||||||||
KEGG |
Regulation of actin cytoskeleton pathway
Pathogenic Escherichia coli infection pathway
Fc gamma R-mediated phagocytosis pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
ErbB1 downstream signaling
RAC1 signaling pathway
CDC42 signaling events
PDGFR-beta signaling pathway
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001024959 NM_001024960 NM_001198780 NM_005718 NM_001198793 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS43047 CCDS46743 CCDS56238 CCDS56237 | ||||||||||||||||||||||
HPRD | 10368 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||