Homo sapiens Gene: LYN
Summary
InnateDB Gene IDBG-408826.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYN
Gene Name v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Synonyms JTK8; p53Lyn; p56Lyn;
Species Homo sapiens
Ensembl Gene ENSG00000254087
Encoded Proteins
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The LYN/PI3K module negatively regulates activation of murine macrophages while Inpp5d (SHIP-1) promotes it.
Overexpression of LYN results in endotoxin hypersensitivity due to the increased activation of dendritic cells leading to an over-production of IFNG by natural killer cells. (Demonstrated in mice)
LYN-dependent phosphorylation of the p110 catalytic subunit of PI 3-kinase is essential to the control of PI 3-kinase biological activity upstream of AKT and thereby to the transactivation of NFκB.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Lyn/PI3K module negatively regulates activation of murine macrophages while Inpp5d (SHIP-1) promotes it.
[Mus musculus] Overexpression of Lyn results in endotoxin hypersensitivity due to the increased activation of dendritic cells leading to an over-production of Ifng by natural killer cells.
[Mus musculus] Lyn regulates the macrophage basal-state signalling checkpoint, and the signalling reorganization initiated by receptor clustering allows cells to discriminate optimally between pathogens and nonpathogens.
Entrez Gene
Summary This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:55879813-56011381
Strand Forward strand
Band q12.1
Transcripts
ENST00000420292
ENST00000519728 ENSP00000428924
ENST00000520220 ENSP00000428424
ENST00000520050 ENSP00000428313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 248 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 248 [view]
Protein-Protein 242 [view]
Protein-DNA 5 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005102 receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0043208 glycosphingolipid binding
GO:0044325 ion channel binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002553 histamine secretion by mast cell
GO:0002576 platelet degranulation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006991 response to sterol depletion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0010976 positive regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030097 hemopoiesis
GO:0030168 platelet activation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031295 T cell costimulation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032868 response to insulin
GO:0033003 regulation of mast cell activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043200 response to amino acid
GO:0043304 regulation of mast cell degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043434 response to peptide hormone
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045646 regulation of erythrocyte differentiation
GO:0046777 protein autophosphorylation
GO:0048678 response to axon injury
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050777 negative regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060252 positive regulation of glial cell proliferation
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 negative regulation of mast cell proliferation
GO:0070668 positive regulation of mast cell proliferation
GO:0071300 cellular response to retinoic acid
GO:0090025 regulation of monocyte chemotaxis
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:1902532 negative regulation of intracellular signal transduction
GO:2000670 positive regulation of dendritic cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030061 mitochondrial crista
GO:0031966 mitochondrial membrane
GO:0034666 alpha2-beta1 integrin complex
GO:0042629 mast cell granule
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL5 pathway
IL6 pathway
RANKL pathway
TSLP pathway
Prolactin pathway
REACTOME
Developmental Biology pathway
FCERI mediated NF-kB activation pathway
FCGR activation pathway
PECAM1 interactions pathway
EPHB-mediated forward signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
CD28 co-stimulation pathway
Platelet Adhesion to exposed collagen pathway
Adaptive Immune System pathway
Immune System pathway
EPHA-mediated growth cone collapse pathway
GPVI-mediated activation cascade pathway
Growth hormone receptor signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Signaling by Interleukins pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Regulation of KIT signaling pathway
FCERI mediated Ca+2 mobilization pathway
Costimulation by the CD28 family pathway
Signaling by the B Cell Receptor (BCR) pathway
CTLA4 inhibitory signaling pathway
Cell surface interactions at the vascular wall pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
Regulation of signaling by CBL pathway
KEGG
Chemokine signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Long-term depression pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
Bcr signaling pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
LPA receptor mediated events
EPO signaling pathway
BCR signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
GMCSF-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
IL5-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001111097 NM_002350 XM_005251233
HUGO
OMIM
CCDS CCDS47859 CCDS6162
HPRD 01301
IMGT
EMBL
GenPept
RNA Seq Atlas