Homo sapiens Gene: PEG10
Summary
InnateDB Gene IDBG-409089.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEG10
Gene Name paternally expressed 10
Synonyms EDR; HB-1; Mar2; Mart2; MEF3L; RGAG3;
Species Homo sapiens
Ensembl Gene ENSG00000242265
Encoded Proteins
paternally expressed 10
paternally expressed 10
paternally expressed 10
paternally expressed 10
paternally expressed 10
paternally expressed 10
paternally expressed 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:94656325-94669695
Strand Forward strand
Band q21.3
Transcripts
ENST00000482108 ENSP00000417587
ENST00000488574 ENSP00000418944
ENST00000493935
ENST00000465184
ENST00000612748 ENSP00000480676
ENST00000613043 ENSP00000482046
ENST00000617526 ENSP00000481101
ENST00000615790 ENSP00000482653
ENST00000612941 ENSP00000478744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001890 placenta development
GO:0006915 apoptotic process
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001040152 NM_001172437 NM_001172438 NM_001184961 NM_001184962 NM_015068
HUGO
OMIM
CCDS CCDS55126 CCDS75636 CCDS75637
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas