Homo sapiens Gene: CHST4
Summary
InnateDB Gene IDBG-40958.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHST4
Gene Name carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Synonyms GlcNAc6ST2; GST3; HECGLCNAC6ST; LSST;
Species Homo sapiens
Ensembl Gene ENSG00000140835
Encoded Proteins
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3\'phosphoadenosine 5\'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5\' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:71525233-71538746
Strand Forward strand
Band q22.2
Transcripts
ENST00000338482 ENSP00000341206
ENST00000539698 ENSP00000441204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006477 protein sulfation
GO:0006790 sulfur compound metabolic process
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007267 cell-cell signaling
GO:0050901 leukocyte tethering or rolling
Cellular Component
GO:0000139 Golgi membrane
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
GO:0031228 intrinsic component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glycosaminoglycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.251383
RefSeq NM_001166395 NM_005769
HUGO
OMIM
CCDS CCDS10902
HPRD 07477
IMGT
EMBL
GenPept
RNA Seq Atlas