Homo sapiens Gene: RPS3A
Summary
InnateDB Gene IDBG-41024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS3A
Gene Name ribosomal protein S3A
Synonyms FTE1; MFTL; S3A;
Species Homo sapiens
Ensembl Gene ENSG00000145425
Encoded Proteins
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
ribosomal protein S3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:151099573-151104652
Strand Forward strand
Band q31.3
Transcripts
ENST00000274065 ENSP00000346050
ENST00000509736 ENSP00000422994
ENST00000507485
ENST00000505243 ENSP00000425024
ENST00000514682 ENSP00000421770
ENST00000515818 ENSP00000425978
ENST00000503002 ENSP00000421277
ENST00000512690 ENSP00000423953
ENST00000508783 ENSP00000421776
ENST00000512797 ENSP00000421457
ENST00000507327 ENSP00000424547
ENST00000515792 ENSP00000425508
ENST00000506126 ENSP00000426282
ENST00000510993 ENSP00000426466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 182 [view]
Protein-Protein 181 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0030154 cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Translation initiation complex formation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RGE0
UniProt Splice Variant
Entrez Gene 8944
UniGene Hs.606561 Hs.710718
RefSeq NM_001006
HUGO HGNC:10421
OMIM 180478 603568
CCDS CCDS3775
HPRD 01606
IMGT
EMBL AC095055
GenPept
RNA Seq Atlas 6189 8944