Homo sapiens Gene: APPL1
Summary
InnateDB Gene IDBG-41092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APPL1
Gene Name adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms APPL; DIP13alpha;
Species Homo sapiens
Ensembl Gene ENSG00000157500
Encoded Proteins
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:57227737-57273468
Strand Forward strand
Band p14.3
Transcripts
ENST00000288266 ENSP00000288266
ENST00000444459 ENSP00000406095
ENST00000482800
ENST00000495803 ENSP00000419644
ENST00000468342
ENST00000464446
ENST00000488530
ENST00000492501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 56 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043422 protein kinase B binding
Biological Process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0046324 regulation of glucose import
GO:0090003 regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0012506 vesicle membrane
GO:0016581 NuRD complex
GO:0031901 early endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
FSH pathway
REACTOME
Apoptosis pathway
Role of DCC in regulating apoptosis pathway
Regulation of Apoptosis pathway
KEGG
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL C9JAB0
UniProt Splice Variant
Entrez Gene 26060
UniGene Hs.476415 Hs.665154 Hs.666225
RefSeq NM_012096
HUGO HGNC:24035
OMIM 604299
CCDS CCDS2882
HPRD 05053
IMGT
EMBL AC093928
GenPept
RNA Seq Atlas 26060