Homo sapiens Gene: IL3
Summary
InnateDB Gene IDBG-41115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL3
Gene Name interleukin 3 (colony-stimulating factor, multiple)
Synonyms IL-3; MCGF; MULTI-CSF;
Species Homo sapiens
Ensembl Gene ENSG00000164399
Encoded Proteins
interleukin 3 (colony-stimulating factor, multiple)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132060529-132063204
Strand Forward strand
Band q31.1
Transcripts
ENST00000296870 ENSP00000296870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 5 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005135 interleukin-3 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0035162 embryonic hemopoiesis
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045740 positive regulation of DNA replication
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
IL3 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
Fc epsilon RI signaling pathway pathway
Asthma pathway
INOH
GPCR signaling pathway
IL-3 signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Il 3 signaling pathway [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
PID NCI
Calcium signaling in the CD4+ TCR pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL3-mediated signaling events
Cross-References
SwissProt P08700
TrEMBL
UniProt Splice Variant
Entrez Gene 3562
UniGene Hs.694
RefSeq NM_000588
HUGO HGNC:6011
OMIM 147740
CCDS CCDS4149
HPRD
IMGT
EMBL AC004511 AF365976 BC066272 BC066273 BC066276 BC069472 M14743 M17115 M20137
GenPept AAA35725 AAA59146 AAA59147 AAC08706 AAH66272 AAH66273 AAH66276 AAH69472 AAK38378
RNA Seq Atlas 3562