Version 5.4
Homo sapiens Gene: GPT
Summary
InnateDB Gene IDBG-41262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPT
Gene Name glutamic-pyruvate transaminase (alanine aminotransferase)
Synonyms AAT1; ALT1; GPT1
Species Homo sapiens
Ensembl Gene ENSG00000167701
Encoded Proteins
IDBP-240541
glutamic-pyruvate transaminase (alanine aminotransferase)
IDBP-586877
glutamic-pyruvate transaminase (alanine aminotransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144502973-144507174
Strand Forward strand
Band q24.3
Transcripts
ENST00000354769
ENST00000394955 ENSP00000378408
ENST00000528431 ENSP00000433586
ENST00000527165
ENST00000531330
ENST00000534702
ENST00000527961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0008652 cellular amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042853 L-alanine catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022546
View Gene Order
ENSBTAG00000007835
Not yet available
Pathways
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.103502
RefSeq NM_005309
HUGO
OMIM
CCDS CCDS6430
HPRD 00689
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca