Homo sapiens Gene: GPT
Summary
InnateDB Gene IDBG-41262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPT
Gene Name glutamic-pyruvate transaminase (alanine aminotransferase)
Synonyms AAT1; ALT1; GPT1;
Species Homo sapiens
Ensembl Gene ENSG00000167701
Encoded Proteins
glutamic-pyruvate transaminase (alanine aminotransferase)
glutamic-pyruvate transaminase (alanine aminotransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144502973-144507174
Strand Forward strand
Band q24.3
Transcripts
ENST00000354769
ENST00000394955 ENSP00000378408
ENST00000528431 ENSP00000433586
ENST00000527165
ENST00000531330
ENST00000534702
ENST00000527961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0008652 cellular amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042853 L-alanine catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Amino acid synthesis and interconversion (transamination) pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
INOH
Alanine Aspartate Asparagine metabolism pathway
Glutamate Glutamine metabolism pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P24298
TrEMBL
UniProt Splice Variant
Entrez Gene 2875
UniGene Hs.103502
RefSeq NM_005309
HUGO HGNC:4552
OMIM 138200
CCDS CCDS6430
HPRD
IMGT
EMBL BC018207 BT006992 CH471162 D10355 EF444981 U70732
GenPept AAC51155 AAH18207 AAP35638 ACA05996 BAA01186 EAW82077 EAW82078
RNA Seq Atlas 2875