InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNRPB

Summary

InnateDB Gene

IDBG-41346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPB

Gene Name

small nuclear ribonucleoprotein polypeptides B and B1

Synonyms

COD; Sm-B/B\'; SmB/B\'; SmB/SmB\'; snRNP-B; SNRPB1

Species

Homo sapiens

Ensembl Gene

ENSG00000125835

Encoded Proteins

IDBP-41348

small nuclear ribonucleoprotein polypeptides B and B1

IDBP-41354

small nuclear ribonucleoprotein polypeptides B and B1

IDBP-362623

small nuclear ribonucleoprotein polypeptides B and B1

IDBP-808198

small nuclear ribonucleoprotein polypeptides B and B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B\') have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:2461634-2470853

Strand

Reverse strand

Band

p13

Transcripts

ENST00000381342	ENSP00000370746
ENST00000339610	ENSP00000342305
ENST00000438552	ENSP00000412566
ENST00000474384	ENSP00000474579

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	113 [view]
Protein-Protein	113 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0071208	histone pre-mRNA DCP binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0008334	histone mRNA metabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0031124	mRNA 3'-end processing
GO:0034660	ncRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005683	U7 snRNP
GO:0005685	U1 snRNP
GO:0005687	U4 snRNP
GO:0005689	U12-type spliceosomal complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030532	small nuclear ribonucleoprotein complex
GO:0034709	methylosome
GO:0034719	SMN-Sm protein complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome
GO:0071204	histone pre-mRNA 3'end processing complex