Homo sapiens Gene: FLNB
Summary
InnateDB Gene IDBG-41570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLNB
Gene Name filamin B, beta
Synonyms ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L; LRS1; SCT; TABP; TAP;
Species Homo sapiens
Ensembl Gene ENSG00000136068
Encoded Proteins
filamin B, beta
filamin B, beta
filamin B, beta
filamin B, beta
filamin B, beta
filamin B, beta
filamin B, beta
filamin B, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:58008400-58172251
Strand Forward strand
Band p14.3
Transcripts
ENST00000295956 ENSP00000295956
ENST00000358537 ENSP00000351339
ENST00000429972 ENSP00000415599
ENST00000419752 ENSP00000414532
ENST00000490882 ENSP00000420213
ENST00000493452 ENSP00000418510
ENST00000481470
ENST00000491408
ENST00000477629
ENST00000466455 ENSP00000420199
ENST00000470231 ENSP00000419954
ENST00000468939
ENST00000475487
ENST00000484981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 70 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007165 signal transduction
GO:0007519 skeletal muscle tissue development
GO:0019221 cytokine-mediated signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0030154 cell differentiation
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
ISG15 antiviral mechanism pathway
KEGG
MAPK signaling pathway pathway
Focal adhesion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O75369
TrEMBL
UniProt Splice Variant
Entrez Gene 2317
UniGene Hs.476448 Hs.574321
RefSeq NM_001457 NM_001164317 NM_001164319 NM_001164318 XM_005264982 XM_005264981
HUGO HGNC:3755
OMIM 603381
CCDS CCDS2885 CCDS54599 CCDS54601 CCDS54600
HPRD 04543
IMGT
EMBL AB191258 AB209889 AB371580 AB371581 AB371582 AC114399 AC137936 AF042166 AF043045 AF191594 AF191595 AF191596 AF191597 AF191598 AF191599 AF191600 AF191601 AF191602 AF191603 AF191604 AF191605 AF191606 AF191607 AF191608 AF191609 AF191610 AF191611 AF191612 AF191613 AF191614 AF191615 AF191616 AF191617 AF191618 AF191619 AF191620 AF191621 AF191622 AF191623 AF191624 AF191625 AF191626 AF191627 AF191628 AF191629 AF191630 AF191631 AF191632 AF191633 AF238609 AF353667 AL137574 BX641085 M62994
GenPept AAA35505 AAC33845 AAC39842 AAF72339 AAF97046 AAL68440 AAL68441 AAL68442 AAL68443 BAD52434 BAD93126 BAG48309 BAG48310 BAG48311 CAB70818 CAE46040
RNA Seq Atlas 2317