Homo sapiens Gene: IRF1
Summary
InnateDB Gene IDBG-42125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF1
Gene Name interferon regulatory factor 1
Synonyms IRF-1; MAR;
Species Homo sapiens
Ensembl Gene ENSG00000125347
Encoded Proteins
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IRF1 is required for the up-regulation of the CD40-NF-kappaB activator 1 (TRAF3IP2 ) axis during airway inflammation.
IRF1 is controlled by two distinct signalling pathways; a JAK/STAT-signalling pathway in viral infected cells and an ATM-signalling pathway in DNA damaged cells.
IRF1 specifically binds to the upstream regulatory region of the human IFN-beta (IFNB1) gene and mediates IFNB1 virus-induced transcription and is involved in the regulation of other genes such as IFN-alpha and MHC class I genes.
IRF1 mediated type I IFN independent mechanism of enhanced RSAD2 (viperin) expression provides a redundant mechanism to protect cells from viral infections.
IRF1 transcriptionally inhibits the IL23A through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS (shown in mice).
IRF1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model. (Demonstrated in mice)
MIR23A contributes to human herpes simplex virus type 1 replication through the regulation of the IRF1-mediated antiviral signal pathway.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Irf1 transcriptionally inhibits the Il23a through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS.
[Mus musculus] Irf1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model.
[Mus musculus] Irf1 is an essential regulator of the host innate antiviral response in the brain by limiting viral replication at later stages of infection, but is not involved in the rapid induction of IFN.
[Mus musculus] Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.
Entrez Gene
Summary IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132481609-132490798
Strand Reverse strand
Band q31.1
Transcripts
ENST00000245414 ENSP00000245414
ENST00000405885 ENSP00000384406
ENST00000437654 ENSP00000405655
ENST00000458069 ENSP00000396318
ENST00000439555 ENSP00000392455
ENST00000472045
ENST00000459982
ENST00000463784
ENST00000476613 ENSP00000473661
ENST00000493208
ENST00000613424 ENSP00000480887
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 206 [view]
Protein-Protein 70 [view]
Protein-DNA 135 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002819 regulation of adaptive immune response
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
Hepatitis C pathway
INOH
PID BIOCARTA
The information processing pathway at the ifn beta enhancer [Biocarta view]
PID NCI
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
IL6-mediated signaling events
Regulation of Telomerase
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436061 Hs.665110 Hs.672951
RefSeq NM_002198
HUGO
OMIM
CCDS CCDS4155
HPRD 00961
IMGT
EMBL
GenPept
RNA Seq Atlas