Version 5.4
Homo sapiens Gene: CHST8
Summary
InnateDB Gene IDBG-42751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHST8
Gene Name carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124302
Encoded Proteins
IDBP-42753
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
IDBP-377310
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
IDBP-377311
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
IDBP-763818
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:33621955-33773509
Strand Forward strand
Band q13.11
Transcripts
ENST00000262622 ENSP00000262622
ENST00000434302 ENSP00000392604
ENST00000438847 ENSP00000393879
ENST00000591231 ENSP00000467012
ENST00000604556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0006790 sulfur compound metabolic process
GO:0007417 central nervous system development
GO:0016051 carbohydrate biosynthetic process
GO:0030166 proteoglycan biosynthetic process
GO:0042446 hormone biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060402
View Gene Order
ENSBTAG00000047670
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.165724
RefSeq NM_001127895 NM_001127896 NM_022467
HUGO
OMIM
CCDS CCDS12433
HPRD 07632
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca