InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNAJC3

Summary

InnateDB Gene

IDBG-43059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC3

Gene Name

DnaJ (Hsp40) homolog, subfamily C, member 3

Synonyms

ERdj6; HP58; P58; P58IPK; PRKRI

Species

Homo sapiens

Ensembl Gene

ENSG00000102580

Encoded Proteins

IDBP-43061

DnaJ (Hsp40) homolog, subfamily C, member 3

IDBP-810353

DnaJ (Hsp40) homolog, subfamily C, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:95677139-95794989

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000376795	ENSP00000365991
ENST00000602402	ENSP00000473631

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0051087	chaperone binding
GO:0051787	misfolded protein binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0051607	defense response to virus

Cellular Component

GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0031205	endoplasmic reticulum Sec complex
GO:0070062	extracellular vesicular exosome